8-[2-(4-fluorophenylamino)-6-propylpyrimidin-4-yl]-8-azabicyclo[3.2.1]octan-3-ol | 1394803-40-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 8-[2-(4-fluorophenylamino)-6-propylpyrimidin-4-yl]-8-azabicyclo[3.2.1]octan-3-ol
• 英文别名: 8-[2-(4-Fluoroanilino)-6-propylpyrimidin-4-yl]-8-azabicyclo[3.2.1]octan-3-ol
• CAS: 1394803-40-7
• 化学式: C₂₀H₂₅FN₄O
• 分子量: 356.443
• InChiKey: SXYFHMFSDRTCQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：Lee Hyun-Joo

  公开号：US20130331377A1

  公开（公告）日：2013-12-12

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT 4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

  本发明提供了一种二氨基嘧啶衍生物或其药用可接受的盐，其制备方法，包含相同物质的药物组合物，以及其用途。该二氨基嘧啶衍生物或其药用可接受的盐作为5-HT4受体激动剂，因此可以有效地用于预防或治疗胃肠蠕动功能障碍，其中包括胃食管逆流病（GERD）、便秘、肠易激综合征（IBS）、消化不良、术后肠麻痹、胃排空延迟、胃轻瘫、肠假性梗阻、药物诱导的肠道延迟传输或糖尿病性胃松弛。
• Diaminopyrimidine derivatives and processes for the preparation thereof
  申请人：Yuhan Corporation

  公开号：US10640490B2

  公开（公告）日：2020-05-05

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

  本发明提供了一种二氨基嘧啶衍生物或其药学上可接受的盐、其制备工艺、包含二氨基嘧啶衍生物或其药学上可接受的盐的药物组合物及其用途。本发明的二氨基嘧啶衍生物或其药学上可接受的盐具有 5-HT4 受体激动剂的功能，因此可用于预防或治疗胃肠道运动功能障碍，即胃肠道疾病之一、如胃食管反流病（GERD）、便秘、肠易激综合征（IBS）、消化不良、术后回肠梗阻、胃排空延迟、胃瘫、肠假性梗阻、药物引起的转运延迟或糖尿病性胃 弛缓。
• US9850227B2
  申请人：——

  公开号：US9850227B2

  公开（公告）日：2017-12-26
• [EN] DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] DÉRIVÉS DE DIAMINOPYRIMIDINE ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：YUHAN CORP

  公开号：WO2012115478A2

  公开（公告）日：2012-08-30

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.