[4-(2-dimethylamino-ethoxy)-phenyl]-acetic acid ethyl ester | 101776-71-0

• 英文名称: [4-(2-dimethylamino-ethoxy)-phenyl]-acetic acid ethyl ester
• 英文别名: [4-(2-Dimethylamino-aethoxy)-phenyl]-essigsaeure-aethylester
• CAS: 101776-71-0
• 化学式: C₁₄H₂₁NO₃
• 分子量: 251.326
• InChiKey: CFUDEGIQGYOFGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.73
• 重原子数：
  18.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N,N-二甲基乙醇胺钠盐 、 N,N-二甲基乙醇胺 、 [4-(2-dimethylamino-ethoxy)-phenyl]-acetic acid ethyl ester 生成 [4-(2-dimethylamino-ethoxy)-phenyl]-acetic acid-(2-dimethylamino-ethyl ester)
  参考文献：
  名称：

  The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

  摘要：

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  DOI：

  10.1007/bf02886269
• 作为产物：
  描述：

  methyl 2-(4-(2-bromoethoxy)phenyl)acetate 在 sodium hydroxide 作用下， 生成 [4-(2-dimethylamino-ethoxy)-phenyl]-acetic acid ethyl ester
  参考文献：
  名称：

  The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

  摘要：

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  DOI：

  10.1007/bf02886269