[Re(CO)3(bis-[1-(2,2-dimethoxyethyl)imidazol-2-ylmethyl](3,4,5-trimethoxy-benzyl)amine)]Br | 1040282-14-1

• 英文名称: [Re(CO)3(bis-[1-(2,2-dimethoxyethyl)imidazol-2-ylmethyl](3,4,5-trimethoxy-benzyl)amine)]Br
• CAS: 1040282-14-1
• 化学式: Br*C₂₉H₃₉N₅O₁₀Re
• 分子量: 883.767
• InChiKey: IXWCBBCQGYODEC-UHFFFAOYSA-M

反应信息

• 作为产物：
  描述：

  bis[1-(2,2-dimethoxy-ethyl)-imidazol-2-ylmethyl](3,4,5-trimethoxybenzyl)amine 、 (NEt4)2[rhenium(I)(bromide)3(carbonyl)3] 以 甲醇 为溶剂， 生成 [Re(CO)3(bis-[1-(2,2-dimethoxyethyl)imidazol-2-ylmethyl](3,4,5-trimethoxy-benzyl)amine)]Br
  参考文献：
  名称：

  Novel ether-containing ligands as potential 99mtechnetium(I) heart agents

  摘要：

  A novel pair of lipophilic cationic technetium complexes utilizing the Tc-99m-tricarbonyl core have been developed and evaluated for cardiac uptake. Di-(pyridyl-2-methyl)amine (DPA) and di-(imidazol-2-ylmethyl)amine (DIA) ligands were functionalized using aliphatic or aromatic ether substituents to provide the ligands 3 and 4. Octahedral complexes with the fac {Tc-99m(CO)(3)(ligand)}(+) configuration were readily formed by reaction of (99m)[Tc(CO)(3)(H2O)(3)](+) with the ether-containing tridentate ligands. The Tc-99m-tricarbonyl complexes, formed in > 90% RCY and > 90% RCP, were stable to transchelation in vitro against molar excesses of cysteine and histidine. Preliminary evaluation in rats after intravenous administration showed that the complexes concentrated in the heart muscle to an extent greater than surrounding tissue and blood. The Tc-99m-complex with derivatized DIA, {Tc-99m(CO)(3)(4)}(+) (8), demonstrated 1.8% ID/g in the heart and a 90:1 heart to blood ratio at 120 min post-injection. These initial results provide support for an expanded evaluation of novel cationic Tc-99m-complexes for cardiac imaging. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2007.08.019