N-(methylsulfonyl)-N-(2-oxo-2-phenylethyl)-N'-phenylacetimidamide | 1514928-42-7

• 英文名称: N-(methylsulfonyl)-N-(2-oxo-2-phenylethyl)-N'-phenylacetimidamide
• CAS: 1514928-42-7
• 化学式: C₁₇H₁₈N₂O₃S
• 分子量: 330.408
• InChiKey: SOCXERQHNDKXGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  66.81
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1-(methylsulfonyl)-4-phenyl-1H-1,2,3-triazole 、 N-乙酰苯胺 在 tetrakis[μ-(αS)-α-(1,1-dimethylethyl)-2,3-dihydro-1H-naphtho[1,8-cd]pyridine-2-acetato-κO:.kappaO']dirhodium(II)(Rh-Rh) 作用下， 以 氯仿 为溶剂， 反应 36.0h， 以37%的产率得到N-(methylsulfonyl)-N-(2-oxo-2-phenylethyl)-N'-phenylacetimidamide
  参考文献：
  名称：

  Stereoselective 1,3-Insertions of Rhodium(II) Azavinyl Carbenes

  摘要：

  Rhodium(II) azavinyl carbenes, conveniently generated from 1-sulfonyl-1,2,3-triazoles, undergo a facile, mild, and convergent formal 1,3-insertion into N-H and O-H bonds of primary and secondary amides, various alcohols, and carboxylic acids to afford a wide range of vicinally bisfunctionalized (Z)-olefins with perfect regio- and stereo-selectivity. Utilizing the distinctive functionality installed through these reactions, a number of subsequent rearrangements and cyclizations expand the repertoire of valuable organic building blocks constructed by reactions of transition-metal carbene complexes, including a-allenyl ketones and amino-substituted heterocycles.

  DOI：

  10.1021/ja408185c