2-fluoro-N-(2-methoxyethyl)prop-2-en-1-amine | 1043447-84-2

• 英文名称: 2-fluoro-N-(2-methoxyethyl)prop-2-en-1-amine
• CAS: 1043447-84-2
• 化学式: C₆H₁₂FNO
• mdl: MFCD19227384
• 分子量: 133.166
• InChiKey: RRLQDTXPFVETOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-fluoro-N-(2-methoxyethyl)prop-2-en-1-amine 、 以 二氯甲烷 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors

  摘要：

  A series of milnacipran analogs containing a heteroaromatic group were synthesized and studied as monoamine transporter inhibitors. Many compounds exhibited higher potency than milnacipran at NET and NET/SERT with no significant change in lipophilicity. For example, compound R-26f was about 10-fold more potent than milnacipran with IC(50) values of 8.7 and 26 nM at NET and SERT, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.04.045