tricarbonyl-rhenium(I)(1+) | 187032-06-0

• 英文名称: tricarbonyl-rhenium(I)(1+)
• CAS: 187032-06-0
• 化学式: C₃O₃Re
• 分子量: 270.238
• InChiKey: AWQNMLNCEVKFRF-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  tricarbonyl-rhenium(I)(1+) 、 2-[2-[5-[2-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]ethynyl]pyridin-2-yl]hydrazinyl]acetic acid 以 not given 为溶剂， 以95%的产率得到
  参考文献：
  名称：

  Linkage Effects on Binding Affinity and Activation of GPR30 and Estrogen Receptors ERα/β with Tridentate Pyridin-2-yl Hydrazine Tricarbonyl−Re/^99mTc(I) Chelates

  摘要：

  We describe a new structural class of neutral tridentate pyridin-2-yl hydrazine chelates for labeling with tricarbonyl Re/99mTc(I) under aqueous conditions and investigate the receptor binding of synthetic estradiol derivatives with the novel G-protein-coupled receptor GPR30 and estrogen receptors ERalpha/beta. The steroid linkage affected the affinity and selectivity of estrogen binding with these receptors. Fluorescence assays based on calcium signaling demonstrate that membrane-permeable chelates 2 and 3 interact with the receptors in whole cells. These results suggest that in vitro assays will facilitate the development of targeted imaging agents for intracellular receptors and the feasibility of targeting GPR30 and ERalpha/beta for diagnostic tumor imaging.

  DOI：

  10.1021/ja066360p