bis(2,4,6-tris(N,N-dimethylaminomethyl)phenoxy)[phtalocyaninato]silicon | 1415224-02-0

• 英文名称: bis(2,4,6-tris(N,N-dimethylaminomethyl)phenoxy)[phtalocyaninato]silicon
• CAS: 1415224-02-0
• 化学式: C₆₂H₆₈N₁₄O₂Si
• 分子量: 1069.4
• InChiKey: GWKRVXYKZYGWNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  bis(2,4,6-tris(N,N-dimethylaminomethyl)phenoxy)[phtalocyaninato]silicon 、 碘甲烷 以 二氯甲烷 为溶剂， 反应 4.0h， 以27.9%的产率得到
  参考文献：
  名称：

  The synthesis, photochemical and biological properties of new silicon phthalocyanines

  摘要：

  Bis[(1-methylpyrrolidin-2-yl)methoxy] [phthalocyaninato] silicon (2), bis[2-azepan-1-yl)ethoxy] [phthalocyaninato] silicon (3) and bis[(2,4,6-tris(N,N-dimethylamminomethyl) phenoxy)] [phthalocyaninato] silicon (4) were prepared and they were quaternized with the excess of iodomethane to obtain the compounds 2Q, 3Q and 4Q respectively. The binding of quaternized 2Q, 3Q and 4Q phthalocyanines (pcs) with calf thymus (CT) DNA was investigated by UV-Vis, fluorescence spectrophotometric methods and gel electrophoresis. The quenching effect of all quaternized pcs on the fluorescence intensity of SYBR Gold (SYBR)-DNA complex was determined. The results indicated that novel pcs exhibit efficient DNA binding activity. Photocleavage of CT-DNA in the presence of 2Q, 3Q and 4Q were determined using gel electrophoresis. All the experimental data proved that these pcs might be the candidates as DNA-targetting PDT agents. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.08.004
• 作为产物：
  描述：

  2,4,6-三(二甲氨基甲基)苯酚 、 酞菁二氯化硅 在 sodium hydride 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 bis(2,4,6-tris(N,N-dimethylaminomethyl)phenoxy)[phtalocyaninato]silicon
  参考文献：
  名称：

  Photodynamic inactivation of pathogenic Gram-negative and Gram-positive bacteria mediated by Si(IV) phthalocyanines bearing axial ammonium units

  摘要：

  DOI：

  10.1016/j.jphotobiol.2022.112502