4-Cyclopropyl-2-ethylimidazol | 42253-49-6

• 英文名称: 4-Cyclopropyl-2-ethylimidazol
• 英文别名: 4-cyclopropyl-2-ethyl-1(3)H-imidazole；2-ethyl-4-cyclopropylimidazole；5-cyclopropyl-2-ethyl-1H-imidazole
• CAS: 42253-49-6
• 化学式: C₈H₁₂N₂
• mdl: MFCD19218248
• 分子量: 136.197
• InChiKey: FLUNJNLHSFPCOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• SMYD Inhibitors
  申请人：EPIZYME, INC.

  公开号：US20170355695A1

  公开（公告）日：2017-12-14

  The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
• SMYD INHIBITORS
  申请人：EPIZYME, INC.

  公开号：US20190322660A1

  公开（公告）日：2019-10-24

  The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmacentically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
• [EN] PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS<br/>[FR] PYRIDINE ET UTILISATION DE COMPOSÉS DE LA PYRIDIMINE COMME INHIBITEURS DE PI3K-GAMMA
  申请人：INCYTE CORP

  公开号：WO2017120194A1

  公开（公告）日：2017-07-13

  The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.