(+/-)-N-(5-Aminopentyl)-1-{[(2-{[2-(methyloxy)ethyl]oxy}ethyl)oxy]acetyl}piperidine-2-carboxamide | 355139-21-8

• 英文名称: (+/-)-N-(5-Aminopentyl)-1-{[(2-{[2-(methyloxy)ethyl]oxy}ethyl)oxy]acetyl}piperidine-2-carboxamide
• 英文别名: N-(5-aminopentyl)-1-[2-[2-(2-methoxyethoxy)ethoxy]acetyl]piperidine-2-carboxamide
• CAS: 355139-21-8
• 化学式: C₁₈H₃₅N₃O₅
• 分子量: 373.493
• InChiKey: IHZADMKAMSNMBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Amine derivatives for the treatment of apoptosis
  申请人：——

  公开号：US20030216427A1

  公开（公告）日：2003-11-20

  The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.

  本发明涉及替代胺衍生物，特别是用作药用活性化合物的替代胺衍生物，以及包含该式（I）的胺衍生物的药物配方。所述替代胺衍生物是Bax功能和/或激活的高效调节剂，特别是抑制剂。本发明还涉及新型替代胺衍生物以及其制备方法。
• AMINE DERIVATIVES FOR THE TREATMENT OF APOPTOSIS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1263730A1

  公开（公告）日：2002-12-11
• US6770656B2
  申请人：——

  公开号：US6770656B2

  公开（公告）日：2004-08-03
• [EN] AMINE DERIVATIVES FOR THE TREATMENT OF APOPTOSIS<br/>[FR] DERIVES D'AMINE DESTINES AU TRAITEMENT DE L'APOPTOSE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2001060798A1

  公开（公告）日：2001-08-23

  The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives of formula (I). Said substituted amine derivatives are efficient modulators, in particular inhibitors, of the Bax function and/or activation. The present invention is furthermore related to novel substituted amine derivatives as well as methods of their preparation.