6'-(2-Amino-2-phenylacetamido)penicillanoyloxymethyl 2-beta-Acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylate 1,1-Dioxide Hydrochloride | 84472-46-8

• 英文名称: 6'-(2-Amino-2-phenylacetamido)penicillanoyloxymethyl 2-beta-Acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylate 1,1-Dioxide Hydrochloride
• 英文别名: [(2S,3R,5R)-3-(acetyloxymethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carbonyl]oxymethyl (2S,5R,6R)-6-[(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride；[(2S,3R,5R)-3-(acetyloxymethyl)-3-methyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carbonyl]oxymethyl (2S,5R,6R)-6-[(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride
• CAS: 84472-46-8
• 化学式: C₂₇H₃₂N₄O₁₁S₂*ClH
• 分子量: 689.164
• InChiKey: JIDUNGVQZVDDGW-BCQIQARHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.62
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  243
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• Bis-esters of alkanediols, pharmaceutical compositions thereof and intermediates therefor
  申请人：PFIZER INC.

  公开号：EP0059046A1

  公开（公告）日：1982-09-01

  6-Acylaminopenicillancyloxymethyl esters and 1-(6-acyl- aminopenicillanoyloxy)ethyl esters of 2-beta-acetoxymethyl-2- alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful as antibacterial agents. The 6-aminopenicillanoyloxymethyl ester, the 1-(6-aminopenicillanoyloxy)ethyl ester and certain other mono-substituted methyl and ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha- carboxylic acid 1,1-dioxide are useful intermediates to the aforesaid antibacterial agents.

  2-beta-acetoxymethyl-2-α-methyl-(5R)penam-3-α-carboxylic acid 1,1-dioxide 的 6-酰氨基青霉烷氧基甲酯和 1-(6-酰氨基青霉烷氧基)乙酯可用作抗菌剂。 2-beta-acetoxymethyl-2-α-methyl-(5R)penam-3-α-carboxylic acid 1,1-dioxide 的 6-氨基青霉烷氧基甲酯、1-(6-氨基青霉烷氧基)乙酯和某些其他单取代甲基和乙酯是上述抗菌剂的有用中间体。
• US4260624A
  申请人：——

  公开号：US4260624A

  公开（公告）日：1981-04-07
• US4364957A
  申请人：——

  公开号：US4364957A

  公开（公告）日：1982-12-21
• US4478748A
  申请人：——

  公开号：US4478748A

  公开（公告）日：1984-10-23