| 1581274-17-0

• CAS: 1581274-17-0
• 化学式: C₁₇H₁₇Cl₂FN₂Pt
• 分子量: 534.32
• InChiKey: IMTCOHLQOBCLEM-FPIMHUBQSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  以 甲苯 为溶剂， 反应 6.0h， 以45.9%的产率得到
  参考文献：
  名称：

  Exploring the Scope of [Pt₂(4-FC₆H₄)₄(μ-SEt₂)₂] as a Precursor for New Organometallic Platinum(II) and Platinum(IV) Antitumor Agents

  摘要：

  The new compound [Pt-2(4-FC6H4)(4)(mu-SEt2)(2)] (A) was prepared and fully characterized. The reactions of compound A with ligands ArCH=NCH2CH2NMe2 (Ar = 2-BrC6H4, 1a; 2,6-Cl2C6H3, 1b; 4-ClC6H4, 1c; 2-Cl,6-FC6H3, 1d) were studied under different conditions and produced platinum(II) compounds [Pt(4-FC6H4)2(ArCH=NCH2CH2NMe2)] (2b-2d), containing a bidentate [N,N'] ligand, as well as cyclometalated platinum(IV) or platinum(II) compounds such as [PtBr(4-FC6H4)(2)(C6H4CH=NCH2CH2NMe2)] (4a) or [PtCl{(3-FC6H3)(2-XC6H3)CH=NCH2CH2NMe2)] (5b: X = Cl; 5d: X = F), containing a tridentate [C,N,N'] ligand and either a five (4a) or a seven (5b, 5d) membered metallacycle. These compounds exhibit a great antiproliferative activity against non-small lung cancer cells (A549), and the best result was obtained for compound 2c (IC50 = 0.3 +/- 0.1 mu M). While compounds 5 alter the mobility of plasmid DNA in a similar way to cisplatin, compound 4 was less efficient in removing the supercoils from DNA. In spite of the very low IC50 value obtained for compound 2c, this compound does not interact with DNA, and it is neither an intercalator nor a topoisomerase 1 inhibitor.

  DOI：

  10.1021/om5000908