5-bromo-2,2-difluoro-4-methylbenzo[d][1,3]dioxole | 765300-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 5-bromo-2,2-difluoro-4-methylbenzo[d][1,3]dioxole
• 英文别名: 5-bromo-2,2-difluoro-4-methylbenzo-1,3-dioxole；5-bromo-2,2-difluoro-4-methyl-1,3-benzodioxole
• CAS: 765300-02-5
• 化学式: C₈H₅BrF₂O₂
• 分子量: 251.027
• InChiKey: ZQGDTIYYEFNNBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-bromo-2,2-difluoro-4-methylbenzo[d][1,3]dioxole 、 联硼酸新戊二醇酯 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium acetate 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 4.0h， 以48%的产率得到2-(2,2-difluoro-4-methylbenzo[d][1,3]dioxol-5-yl)-5,5-dimethyl-1,3,2-dioxaborinane
  参考文献：
  名称：

  US2014/274701

  摘要：

  公开号：
• 作为产物：
  描述：

  4-methylbenzo-1,3-dioxole-2-thione 在 pyridine*BrF3 作用下， 以35%的产率得到5-bromo-2,2-difluoro-4-methylbenzo[d][1,3]dioxole
  参考文献：
  名称：

  Pyridine•BrF₃, the Missing Link for Clean Fluorinations of Aromatic Derivatives

  摘要：

  This work demonstrates the unique features of the never used before Py center dot BrF3 complex in the field of aromatic organic fluorinations. The main disadvantage of the noncomplexed BrF3 is the fact that usually, in addition to the desired fluorination, a parallel electrophilic aromatic bromination takes place as well. Use of the Py center dot BrF3 complex reduces this electrophilic bromination, which is observed with most reagents based on fluorine and bromine [BrF].

  DOI：

  10.1021/ol3000348

文献信息

• FUNGICIDAL COMPOSITION CONTAINING CARBOXYLIC ACID AMIDE DERIVATIVE
  申请人：Nakamura Yuji

  公开号：US20100222337A1

  公开（公告）日：2010-09-02

  Conventional fungicidal compositions have had practical problems such that either a preventive effect or a curative effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon the application site, and a fungicidal composition to overcome such problems has been desired. The present invention provides a fungicidal composition containing a carboxylic acid amide derivative of the formula (I) or a salt thereof, as an active ingredient: wherein A is phenyl which may be substituted, benzodioxolanyl which may be substituted, or benzodioxanyl which may be substituted; B is 2- or 3-pyridyl which may be substituted; each of R 1 and R 2 is alkyl, or R 1 and R 2 may together form a 3- to 6-membered saturated carbon ring, provided that when B is 3-pyridyl which may be substituted, A is phenyl substituted by at least two substituents.

  传统的杀菌剂组合物存在实际问题，例如预防效果或治疗效果不足，残留效果往往不足，或者根据应用场所，对植物疾病的控制效果往往不足，因此需要一种克服这些问题的杀菌剂组合物。本发明提供了一种含有式(I)的羧酸酰胺衍生物或其盐作为活性成分的杀菌剂组合物：其中A是苯基，可以是取代的苯基，苯并二氧杂环基，可以是取代的苯并二氧杂环基，或苯并二氧杂环基，可以是取代的苯并二氧杂环基；B是2-或3-吡啶基，可以是取代的；R1和R2中的每一个都是烷基，或者R1和R2可以共同形成3-至6-成员的饱和碳环，但是当B是可以被取代的3-吡啶基时，A是至少被两个取代基取代的苯基。
• 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
  申请人：Dow AgroSciences LLC

  公开号：US09149038B2

  公开（公告）日：2015-10-06

  Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

  新型的4-氨基-6-(杂环)吡啶酸及其衍生物和6-氨基-2-(杂环)嘧啶-4-羧酸酯及其衍生物可用于控制不良植被。
• 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES
  申请人：Dow AgroSciences LLC

  公开号：EP3640249A1

  公开（公告）日：2020-04-22

  Novel 4-amino-6-(heterocyclic)picolinic acids and their derivatives and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives are useful to control undesirable vegetation.

  新型 4-氨基-6-(杂环)吡啶甲酸及其衍生物和 6-氨基-2-(杂环)嘧啶-4-羧酸及其衍生物可用于控制不良植被。
• US20140274701A1
  申请人：——

  公开号：——

  公开（公告）日：——
• US8420572B2
  申请人：——

  公开号：US8420572B2

  公开（公告）日：2013-04-16