1-(3-isopropoxy-phenyl)-ethylamine | 854304-17-9

• 英文名称: 1-(3-isopropoxy-phenyl)-ethylamine
• 英文别名: 1-(3-Isopropoxy-phenyl)-aethylamin；1-(3-Isopropoxyphenyl)ethanamine；1-(3-propan-2-yloxyphenyl)ethanamine
• CAS: 854304-17-9
• 化学式: C₁₁H₁₇NO
• mdl: MFCD09434007
• 分子量: 179.262
• InChiKey: HYWTVQKMPIPXGT-UHFFFAOYSA-N

物化性质

• 沸点：
  145 °C(Press: 13 Torr)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium amalgam 作用下， 生成 1-(3-isopropoxy-phenyl)-ethylamine
  参考文献：
  名称：

  756. α -Methylbenzylamines。第二部分 3-环己氧基-4-羟基-α-甲基苄胺，其脱氧衍生物及相关醚

  摘要：

  DOI：

  10.1039/jr9510003430

文献信息

• 3-(PYRIMIDIN-4-YL)-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
  申请人：Novartis AG

  公开号：EP2771337B1

  公开（公告）日：2017-08-02
• [EN] N-BENZYLINDOLE MODULATORS OF PPARG<br/>[FR] MODULATEURS N-BENZYLINDOLE DU PPARG
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2012170561A1

  公开（公告）日：2012-12-13

  The invention provides molecular entities that bind with high affinity to PPARG (PPARγ), and inhibit kinase-mediated (e.g., cdk5-mediated) phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes, insulin resistance, impaired glucose tolerance, pre-diabetes, hyperglycemia, hyperinsulinemia, obesity, or inflammation. Side effects of significant weight gain, edema, impairment of bone growth or formation, or cardiac hypertrophy, or any combination thereof, can be avoided in the mammal receiving the compound. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.