[Cu(2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)pyridine)(N3)(ClO4)]2 | 1337970-57-6

• 英文名称: [Cu(2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)pyridine)(N3)(ClO4)]2
• CAS: 1337970-57-6
• 化学式: C₃₄H₂₈Cl₂Cu₂N₁₄O₈
• 分子量: 958.683
• InChiKey: DNAGLYUAWOSCOQ-YFGZETJNSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  copper(II) perchlorate hexahydrate 、 (1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine) 、 sodium azide 以 甲醇 为溶剂， 以78%的产率得到[Cu(2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)pyridine)(N3)(ClO4)]2
  参考文献：
  名称：

  DNA interaction, superoxide scavenging and cytotoxicity studies on new copper(II) complexes derived from a tridentate ligand

  摘要：

  The copper complexes [Cu(Pyimpy)(H2O)](ClO4)(2) (1), [Cu(Pyimpy)(2)](ClO4)(2) (2), [Cu(Pyimpy)(2)](Cl)(2)]center dot 2H(2)O(3 center dot 2H(2)O), [Cu(Pyimpy)(N-3)(ClO4)](2) (4) and [Cu(Pyimpy)(SCN)(ClO4)](2) (5) were synthesized and characterized by spectroscopic techniques, crystal structures and electrochemical studies (Pyimpy: (2-((2-phenyl-2-(pyridin-2-l)hydrazono)methyl)pyridine)). The superoxide scavenging activity of the two water soluble complexes 1 and 3 was examined. DNA interaction studies by UV-Vis absorption spectral changes during a titration experiment indicated the generation of new species. These small molecule SOD mimics exhibited excellent DNA cleavage activity in the presence of H2O2 as well as 2-mercaptoethanol. Complexes 1-5 exhibited better cytotoxicity compared to CuCl2 center dot 2H(2)O and the ligand Pyimpy, and showed more potency than cisplatin for MCF-7, PC-3 and HEK-293 cells. Complex 3 exhibited the highest potency for MCF-7, PC-3 and HEK-293 cells compared to the other complexes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.07.019