[Pd(5-deoxy-3-O-ferrocenoyl-1,2-O-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazole-1-yl)-α-D-xylofuranose)Cl₂] | 1613038-66-6

• 英文名称: [Pd(5-deoxy-3-O-ferrocenoyl-1,2-O-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazole-1-yl)-α-D-xylofuranose)Cl₂]
• CAS: 1613038-66-6
• 化学式: C₂₆H₂₆Cl₂FeN₄O₅Pd
• 分子量: 707.689
• InChiKey: NRZWLXYKSYRQTB-YCNWETFZSA-L

反应信息

• 作为产物：
  描述：

  dichloro(cycloocta-1,5-diene)palladium (II) 、 5-deoxy-3-O-ferrocenoyl-1,2-O-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazole-1-yl)-α-D-xylofuranose 以 二氯甲烷 为溶剂， 反应 2.0h， 以76%的产率得到[Pd(5-deoxy-3-O-ferrocenoyl-1,2-O-isopropylidene-5-(4-(2-pyridyl)-1H-1,2,3-triazole-1-yl)-α-D-xylofuranose)Cl₂]
  参考文献：
  名称：

  Palladium(II) carbohydrate complexes of alkyl, aryl and ferrocenyl esters and their cytotoxic activities

  摘要：

  This article describes the synthesis and cytotoxic activities of palladium(II) carbohydrate complexes of methyl, phenyl and ferrocenyl ester derivatives. The 3-O-ferrocenoyl-1,2-O-isopropylidene-alpha-D-xylofuranose triazole (2c) was prepared by the Huisgen 1,3-dipolar cycloaddition reaction of 2-ethynyl pyridine and 5-azido-5-deoxy-3-O-ferrocenoyl-1,2-O-isopropylidene-alpha-D-xylofuranose (1c). The reaction of this conjugate with [Pd(COD)Cl-2] in anhydrous dichloromethane formed the corresponding palladium(II) complex (3c). The ligands and the complexes were characterised by H-1 NMR, ESI mass, IR and elemental analysis. The UV-Vis and CV studies were also performed for the metal complexes. The electronic absorption spectra of complexes 3a-c shows the presence of both triazole and ferrocene absorption bands. Electrochemical studies of complexes 3a-c show the presence of a reduction peak at around -0.84 V thereby indicating the conversion of Pd(II) to Pd(0). The in vitro cytotoxic activity was studied against a panel of four different cancer cell lines. It was observed that these compounds exhibited significant cytotoxicity specifically on A549 cancer cell line. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.03.018