N-[2-(2-hydroxyethoxy)ethyl]-2-[8-[2-[2-(2-hydroxyethoxy)ethylamino]-2-oxoethyl]-4,11-bis(pyridin-2-ylmethyl)-1,4,8,11-tetrazacyclotetradec-1-yl]acetamide | 1202573-14-5

• 英文名称: N-[2-(2-hydroxyethoxy)ethyl]-2-[8-[2-[2-(2-hydroxyethoxy)ethylamino]-2-oxoethyl]-4,11-bis(pyridin-2-ylmethyl)-1,4,8,11-tetrazacyclotetradec-1-yl]acetamide
• CAS: 1202573-14-5
• 化学式: C₃₄H₅₆N₈O₆
• 分子量: 672.869
• InChiKey: JLBCFIMBQGOMTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  48
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  156
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  bismuth (III) nitrate pentahydrate 、 N-[2-(2-hydroxyethoxy)ethyl]-2-[8-[2-[2-(2-hydroxyethoxy)ethylamino]-2-oxoethyl]-4,11-bis(pyridin-2-ylmethyl)-1,4,8,11-tetrazacyclotetradec-1-yl]acetamide 以 乙醇 为溶剂， 以95%的产率得到
  参考文献：
  名称：

  Bismuth (III) coordination to cyclen and cyclam bearing four appended groups

  摘要：

  The synthesis of new cyclam and cyclen derivatives (respectively L-1 and L-2), able to efficiently coordinate to Bi(III) are presented here. The two ligands bearing two different pendant arms (two-pycolyl and two (2-(2-hydroxyethoxy)ethyl)-2-aminoacetamide in trans position) were synthesized in the aim to obtain stable and water soluble complexes. The thermodynamic and kinetic of the formation of the corresponding complexes in aqueous solution were studied by means of NMR and potentiometric investigations. The fast kinetic of complexation and the high stability of the complexes are encouraging for further application with the alpha-emitting Bi-213 isotope. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2009.08.003