[Fe(N'-phenyl-N'-(pyridin-2-yl)picolinohydrazide)(MeOH)Cl₂] | 1569105-56-1

• 英文名称: [Fe(N'-phenyl-N'-(pyridin-2-yl)picolinohydrazide)(MeOH)Cl₂]
• 英文别名: [Fe(Pamp)(MeOH)Cl₂]
• CAS: 1569105-56-1
• 化学式: C₁₈H₁₇Cl₂FeN₄O₂
• 分子量: 448.112
• InChiKey: VFMZESGXGGAPOL-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  iron(III) chloride 、 N’-phenyl-N’-(pyridin-2-yl)picolinohydrazide 以 甲醇 为溶剂， 反应 3.0h， 以42%的产率得到[Fe(N'-phenyl-N'-(pyridin-2-yl)picolinohydrazide)(MeOH)Cl₂]
  参考文献：
  名称：

  Synthesis, structure, redox properties and DNA interaction studies on mononuclear iron(III) complexes with amidate ligand

  摘要：

  A new family of mononuclear Fe(III) complexes [Fe(Pamp)(MeOH) Cl-2], 1 and [Fe(Pamp)(2)](ClO4), 2 were synthesized using designed tridentate ligand PampH having pyridine and amide nitrogen donors (PampH is NO-phenyl-NO-(pyridin-2-yl) picolinohydrazide) and H stands for dissociable proton). Both the complexes (1 and 2) were characterized by different spectroscopic studies and molecular structure of [Fe(Pamp)(2)](ClO4), 2 was determined by single crystal X-ray diffraction. Geometry around metal centre was described as distorted octahedral with two meridionally oriented Pamp ligands. Electrochemical studies afforded E1/2 values of Fe(III)/Fe(II) couple + 0.065 V (for 1) and 0.077 V (for 2) versus Ag/AgCl electrode. DNA binding properties of these complexes were investigated and complex 1 exhibited nuclease activity. Mechanistic investigation revealed the possible participation of hydroxyl radical in nuclease activity which was supported by rhodamine B assay. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.11.034