trans-dichlorobis(1,2-bis(propylsulfinyl)ethane)ruthenium(II) | 197771-54-3

• 英文名称: trans-dichlorobis(1,2-bis(propylsulfinyl)ethane)ruthenium(II)
• 英文别名: trans-RuCl₂(1,2-bis(propylsulfinyl)ethane)₂
• CAS: 197771-54-3
• 化学式: C₁₆H₃₆Cl₂O₄RuS₄
• 分子量: 592.699
• InChiKey: VWVOZAGYDCTHTE-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,2-bis(propylsulfinyl)ethane 、 dichlorotetrakis(dimethylsulfoxide)ruthenium(II) 以 甲醇 为溶剂， 反应 3.0h， 以47%的产率得到trans-dichlorobis(1,2-bis(propylsulfinyl)ethane)ruthenium(II)
  参考文献：
  名称：

  新型二亚砜及其钌配合物的合成与表征

  摘要：

  摘要报道了通过氧化相应的十种新的二亚砜和四种已知的RS（O）–CH2）n-（O）SR（n = 2或3，R =烷基）形成的合成方法二硫醚，RS（CH2）nSR，使用DMSO或H2O2的酸性溶液作为氧化剂。然后将二氧化硫与市售的RuCl3·H2O，K3（RuCl6）或所谓的Ru'Blue'或'Red'溶液在水溶液或醇（MeOH，EtOH）溶液中反应，从中可以形成各种S键合的亚磺酰基络合物分离出顺式或反式RuIICl2（二亚砜）2型的[RuIICl2（二亚砜）（H2O）] 2（μ-Cl）2和[Ru2II / IIICl（二亚砜）] 2（μ-Cl）3；包括X射线数据在内的所有这三种类型都具有良好的特征。还合成了一种具有桥联二亚砜1,2-双（苯基亚磺酰基）乙烷的RuCl3（BPhSE）] 2（μ-BPhSE）的RuIII配合物，但表征较差。

  DOI：

  10.1016/j.ica.2019.119217

文献信息

• Bidentate Sulfoxide Complexes of Ruthenium(II) and Their Preliminary Biological Assessment <i>in Vitro</i>
  作者：Donald T. T. Yapp、Steven J. Rettig、Brian R. James、Kirsten A. Skov

  DOI：10.1021/ic9606486

  日期：1997.11.1

  The complexes trans-RuCl2(BMSE)(2) (1), cis-RuCl2(BESE)(2) (2), trans-RuCl2(BPSE)(2) (3), and cis-RuCl2(BMSP)(2) (4) have been synthesized and characterized, including X-ray analyses [BMSE = 1,2-bis(methylsulfinyl)ethane, BESE = 1,2-bis(ethylsulfinyl)ethane, BPSE = 1,2-bis(propylsulfinyl)ethane, and BMSP = 1,3-bis(methylsulfinyl)propane]. Crystal data are as follows: 1 . H2O, triclinic, P1, a 8.863(1) Angstrom, b = 14.462(3) Angstrom, c 7.543(1) Angstrom, alpha = 103.39(1)degrees, beta = 113.31(1)degrees, gamma = 77.23(1)degrees, 2=2; 2 . MeOH, triclinic, , n 14.858(2) Angstrom, b = 16.732(3) Angstrom, c 10.609(2) Angstrom, alpha 105.14(2)degrees, beta 93.34(2)degrees, gamma = 115.91(1)degrees, Z= 4; 3, orthorhombic, Aba2, a = 14.894(1) Angstrom, b = 7.501(1) Angstrom, c = 21.911(2) Angstrom, Z = 4; 4, orthorhombic, Pcab, a = 15.257(3) Angstrom, b = 18.138(2) Angstrom, c = 13.395(2) Angstrom, Z = 8. The structures were solved by the Patterson method and were refined by full-matrix least-squares procedures to R = 0.026, 0.026, 0.029, and 0.031 for 10461, 8952, 1594, and 5694 reflections with I > 3 sigma(I), for 1-4, respectively. Preliminary in vitro experiments with Chinese hamster ovary cells indicate that the trans-complexes accumulate in the cells and bind to DNA to a greater degree than the cis-complexes.