methyl 2-ethoxy-2',3'-methylenedioxy-6-propoxycarbonyl-3,4,4'-trimethoxy-1,1'-biphenyl-6'-carboxylate | 118503-21-2

• 英文名称: methyl 2-ethoxy-2',3'-methylenedioxy-6-propoxycarbonyl-3,4,4'-trimethoxy-1,1'-biphenyl-6'-carboxylate
• 英文别名: methyl 4-(2-ethoxy-3,4-dimethoxy-6-propoxycarbonylphenyl)-7-methoxy-1,3-benzodioxole-5-carboxylate
• CAS: 118503-21-2
• 化学式: C₂₄H₂₈O₁₀
• 分子量: 476.48
• InChiKey: FDTVNTLKDMPPHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  methyl 2-ethoxy-2',3'-methylenedioxy-6-propoxycarbonyl-3,4,4'-trimethoxy-1,1'-biphenyl-6'-carboxylate 以86%的产率得到
  参考文献：
  名称：

  KIMURA, MASAYUKI;HOSAKA, KUNIO;TAKEDA, SHIGEHUMI;MITSUHASHI, HIROSHI

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-oxomethylenedioxy-2',3'-methylenedioxy-4,4'-dimethoxy-6'-methoxycarbonyl-1,1'-biphenyl-6-carboxylic acid 以60%的产率得到
  参考文献：
  名称：

  KIMURA, MASAYUKI;HOSAKA, KUNIO;TAKEDA, SHIGEHUMI;MITSUHASHI, HIROSHI

  摘要：

  DOI：

文献信息

• Novel biphenyl derivative and preparation and use thereof
  申请人：Tsumura & Co.

  公开号：US04996331A1

  公开（公告）日：1991-02-26

  The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action and effective as a remedy for acute hepatitis and chronic hepatitis, a process for the preparation of this biphenyl derivative and a liver ailment-moderating agent comprising this diphenyl derivative as an effective ingredient. This diphenyl derivative is represented by the following formula: ##STR1## wherein R.sub.0 and R.sub.1 independently stand for a lower alkyl group or R.sub.0 and R.sub.1 together represent a group O.dbd.C<, R.sub.2 stands for an alkyl group having 1 to 3 carbon atoms, and R.sub.3 and R.sub.4 independently stand for a hydrogen atom or a lower alkyl group.

  本发明涉及一种新型的二苯基衍生物，具有调节肝功能的作用，并可作为急性肝炎和慢性肝炎的治疗药物，制备这种二苯基衍生物的方法以及包含该二苯基衍生物作为有效成分的肝功能调节剂。该二苯基衍生物由以下式子表示：##STR1## 其中R.sub.0和R.sub.1独立地代表较低的烷基或R.sub.0和R.sub.1共同代表O.dbd.C<的基团，R.sub.2代表具有1至3个碳原子的烷基，R.sub.3和R.sub.4独立地代表氢原子或较低的烷基。
• Biphenyl derivative and preparation and use thereof
  申请人：Tsumura & Co.

  公开号：US05264594A1

  公开（公告）日：1993-11-23

  The present invention relates to a novel biphenyl derivative having a liver ailment-moderating action and effective as a remedy for acute hepatitis and chronic hepatitis, a process for the preparation of this biphenyl derivative and a liver ailment-moderating agent comprising this diphenyl derivative as an effective ingredient. This diphenyl derivative is represented by the following formula: ##STR1## wherein R.sub.0 and R.sub.1 independently stand for a lower alkyl group or R.sub.0 and R.sub.1 together represent a group O.dbd.C<, R.sub.2 stands for an alkyl group having 1 to 3 carbon atoms, and R.sub.3 and R.sub.4 independently stand for a hydrogen atom or a lower alkyl group.

  本发明涉及一种具有调节肝脏疾病作用的新型联苯衍生物，可作为急性肝炎和慢性肝炎的治疗药物，以及制备此联苯衍生物的方法和以该联苯衍生物为有效成分的肝脏疾病调节剂。该联苯衍生物由以下公式表示：##STR1## 其中，R.sub.0和R.sub.1分别代表较低的烷基或R.sub.0和R.sub.1在一起代表O.dbd.C<的基团，R.sub.2代表具有1至3个碳原子的烷基，R.sub.3和R.sub.4独立地代表氢原子或较低的烷基。
• NOVEL BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE
  申请人：TSUMURA & CO.

  公开号：EP0267970A1

  公开（公告）日：1988-05-25

  Novel biphenyl derivatives having a liver trouble-relieving effect, process for their preparation, and liver trouble-relieving agents containing them as effective ingredients. The biphenyl derivatives are represented by formula (I), wherein Ro and R1 each independently represents a lower alkyl group or, then taken together, represent 0=C<, R2 represents a C1-3 alkyl group, and R3 and R4 each represents a hydrogen atom or a lower alkyl group.

  具有缓解肝病效果的新型联苯衍生物、其制备工艺以及含有它们作为有效成分的缓解肝病制剂。 联苯衍生物由式（I）表示，其中Ro和R1各自独立地代表一个低级烷基或合在一起代表0=C<，R2代表一个C1-3烷基，R3和R4各自代表一个氢原子或一个低级烷基。
• US4849448A
  申请人：——

  公开号：US4849448A

  公开（公告）日：1989-07-18
• US4925872A
  申请人：——

  公开号：US4925872A

  公开（公告）日：1990-05-15