chlorido(1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine)copper(II) perchlorate | 1257416-36-6

• 英文名称: chlorido(1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine)copper(II) perchlorate
• CAS: 1257416-36-6
• 化学式: C₁₇H₁₄Cl₂CuN₄O₄
• 分子量: 472.775
• InChiKey: UXRMHTRVJUVQCH-YOQVYELISA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  copper(II) perchlorate hexahydrate 、 (1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine) 、 四乙基氯化铵 以 甲醇 为溶剂， 生成 chlorido(1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine)copper(II) perchlorate
  参考文献：
  名称：

  Synthesis, structural characterization and DNA interaction studies on a mononuclear copper complex: Nuclease activity via self-activation

  摘要：

  Mononuclear copper(II) complex [Cu(Pyimpy)(Cl)(ClO4)] has been synthesized from a tridentate ligand Pyimpy (Pyimpy = 1-phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine) and characterized by elemental analysis, electronic absorption and IR spectroscopy. Molecular structure of 1 was determined by single crystal X-ray diffraction. Structural index parameter (tau) calculation supported distorted square pyramidal geometry around the metal centre. The stabilization of copper(II) centre was examined by electrochemical studies. DNA interaction studies were investigated by absorption spectral studies and EthBr displacement assay. Nuclease activity studies afforded cleavage of pBR322 plasmid DNA via self-activating mechanism. Investigation of mechanism indicated the possible role of reactive oxygen species in DNA cleavage. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2011.01.008