[CuCl(2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-phenylhydrazinecarbothioamide)((C7H5O2)CHN2C(S)NHPh)] | 1352827-25-8

• 英文名称: [CuCl(2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-phenylhydrazinecarbothioamide)((C7H5O2)CHN2C(S)NHPh)]
• CAS: 1352827-25-8
• 化学式: C₃₀H₂₅ClCuN₆O₄S₂
• 分子量: 696.697
• InChiKey: RSKLZGCUULOFAT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-phenylhydrazinecarbothioamide 以 乙醇 为溶剂， 生成 [CuCl(2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-phenylhydrazinecarbothioamide)((C7H5O2)CHN2C(S)NHPh)]
  参考文献：
  名称：

  Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides

  摘要：

  A series of copper complexes were synthesized from benzo[d][1,3]dioxole-5-carbaldehyde (piperonal) thiosemicarbazones (RHpTSC where R = H, CH3, C2H5 or C6H5 (Ph)). The complexes show interesting variations in geometry depending on the thiosemicarbazone; a dinuclear complex [Cu(HpTSC)Cl]2, a mononuclear complex [Cu(RHpTSC)2Cl2] (R = CH3 or C2H5) and another mononuclear complex [Cu(PhHpTSC)(PhpTSC)Cl] was generated. The complexes bind in a moderately strong fashion to DNA with binding constants on the order of 10(4)M(-1). They are also strong binders of human serum albumin with binding constants near 10(4) M-1. The complexes show good in vitro cytotoxic profiles against two human colon cancer cell lines (HT-116 and HT29) and two human breast cancer cell lines (MCF-7 and MDA-MB-231) with IC50 values in the low millimolar concentration range. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2011.10.032