chloro(N-methyliminodiacetato)palladium(II) | 765887-13-6

• 英文名称: chloro(N-methyliminodiacetato)palladium(II)
• 英文别名: [Pd(mida)Cl](1-)
• CAS: 765887-13-6
• 化学式: C₅H₇ClNO₄Pd
• 分子量: 286.988
• InChiKey: MDTZRDSFDYSRGO-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  chloro(N-methyliminodiacetato)palladium(II) 、 水 在 silver perchlorate 作用下， 以 水 为溶剂， 生成 aqua(N-methyliminodiacetato)palladium(II)
  参考文献：
  名称：

  Reactivity of chloro(N-methyliminodiacetato)palladium(II) and chloro(pyridyl-2,6-dicarboxylato)palladium(II) complexes with purine based 5′-nucleotides and glutathione: antitumor activity of platinum(II)-analogs

  摘要：

  The interaction of [Pd-II(mida)(Cl)] (1) (mida(2) - = N-methyliminodiacetate) and [Pd-II(pydc)(Cl)] (2) (pydc(2) = pyridyl-2,6-dicarboxylate) with adenosine-5'-monophosphate (AMP), inosine-5'-monophosphate (IMP) and glulathione (GSH) wits studied kinetically as a function of [L] (L = AMP, IMP, GSH) and [Cl] and temperatures (10 - 35 degrees C) at pH 4.0. The kinetic results suggest that the reaction of I and 2 with the 5'-nucleotides (AMP, IMP) is characterized by the hydrolysis of chloro-complexes followed by the aquo-substitution with purine based 5'-nucleotides through its N7 atom. The reaction of 1 and 2 with GSH takes place through the direct chloride replacement with GSH. Kinetic data and activation parameters are interpreted in terms or an associative mechanism and discussed in reference to the data reported earlier. The [Pt-II(mida)(Cl)](-) (3) and [Pt-II(pydc)(Cl)] (4)complexes were prepared and allowed to interact with AMP and IMP and their reaction products were characterized by H-1 NMR Studies. The antitumor activity of 3 and 4 was examined against MCF-7 (breast cancer), NCI-11460 (lung cancer) and SF-268 (CNS) cell lines. (c) 2004 Published by Elsevier B.V.

  DOI：

  10.1016/j.ica.2004.09.016
• 作为产物：
  描述：

  盐酸 、 aqua(N-methyliminodiacetato)palladium(II) 以 水 为溶剂， 生成 chloro(N-methyliminodiacetato)palladium(II)
  参考文献：
  名称：

  Reactivity of chloro(N-methyliminodiacetato)palladium(II) and chloro(pyridyl-2,6-dicarboxylato)palladium(II) complexes with purine based 5′-nucleotides and glutathione: antitumor activity of platinum(II)-analogs

  摘要：

  The interaction of [Pd-II(mida)(Cl)] (1) (mida(2) - = N-methyliminodiacetate) and [Pd-II(pydc)(Cl)] (2) (pydc(2) = pyridyl-2,6-dicarboxylate) with adenosine-5'-monophosphate (AMP), inosine-5'-monophosphate (IMP) and glulathione (GSH) wits studied kinetically as a function of [L] (L = AMP, IMP, GSH) and [Cl] and temperatures (10 - 35 degrees C) at pH 4.0. The kinetic results suggest that the reaction of I and 2 with the 5'-nucleotides (AMP, IMP) is characterized by the hydrolysis of chloro-complexes followed by the aquo-substitution with purine based 5'-nucleotides through its N7 atom. The reaction of 1 and 2 with GSH takes place through the direct chloride replacement with GSH. Kinetic data and activation parameters are interpreted in terms or an associative mechanism and discussed in reference to the data reported earlier. The [Pt-II(mida)(Cl)](-) (3) and [Pt-II(pydc)(Cl)] (4)complexes were prepared and allowed to interact with AMP and IMP and their reaction products were characterized by H-1 NMR Studies. The antitumor activity of 3 and 4 was examined against MCF-7 (breast cancer), NCI-11460 (lung cancer) and SF-268 (CNS) cell lines. (c) 2004 Published by Elsevier B.V.

  DOI：

  10.1016/j.ica.2004.09.016