[Os(CO)10(μ-η2-quinoline-4-carboxaldehyde(1-)-N,C(8))(μ-H)] | 656260-42-3

• 英文名称: [Os(CO)10(μ-η2-quinoline-4-carboxaldehyde(1-)-N,C(8))(μ-H)]
• 英文别名: [Os3(CO)10(μ-η2-(4-CHO)C9H5N)(μ-H)]
• CAS: 656260-42-3
• 化学式: C₂₀H₇NO₁₁Os₃
• 分子量: 1007.88
• InChiKey: NCUSOBWTIAXVOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  [Os(CO)10(μ-η2-quinoline-4-carboxaldehyde(1-)-N,C(8))(μ-H)] 以 二氯甲烷 为溶剂， 以31%的产率得到[Os3(CO)9(μ-η2-(4-CHO)C9H5N)(μ-H)]
  参考文献：
  名称：

  Synthesis, Reduction Chemistry, and Spectroscopic and Computational Studies of Isomeric Quinolinecarboxaldehyde Triosmium Clusters

  摘要：

  The quinoline derivatives Os-3(CO)(n)(mu(m)-eta(2)-L-H)(mu-H) (L = quinoline-4-carboxaldehyde, n 10, m = 2, 4; n = 9, N-C(8) bound, m = 3, 5; n = 10, N-C(2) bound, m = 2, 6; L = quinoline-3-carboxaldehyde, n = 9, N-C(8) bound, m = 3, 7) are obtained by the reaction of Os-3(CO)(10)(CH3CN)(2) with the quinoline-3-carboxaldehyde or -4-carboxaldehyde ligand followed by photochemical decarbonylation in the case of 5 and 7. The quinoline-4-carboxaldehyde clusters and the free ligand all show reversible 1e(-) reductions, but the electron-deficient 5 shows two separate reversible 1e(-) reductions, the first at much less negative potential than for the previously investigated Os-3(Co)(9)(mu(3)-eta(2) -L-H)(mu-H) (L = phenanthridine, 1; L = 5,6-benzoquinoline, 2), while the free ligand is reduced at a more negative potential than any of the clusters. The spectroscopic properties of the clusters upon electrochemical and chemical reduction have been investigated, and in the case of 4 selective line broadening of its H-1 NMR resonances is observed. Infrared spectrophotoelectrochemistry reveals that the CO stretching modes are shifted to lower frequencies, as expected. The pattern of unpaired spin densities in the reduced clusters predicted from the DFT calculations correlates with the observed selective line broadening, and EPR measurements confirm the formation of the radical anions at g values similar to those observed for pure organic radical anions.

  DOI：

  10.1021/om030564m
• 作为产物：
  描述：

  4-喹啉甲醛 、 bis(acetonitrile)decacarbonyltriosmium 以 二氯甲烷 为溶剂， 以33%的产率得到[Os(CO)10(μ-η2-quinoline-4-carboxaldehyde(1-)-N,C(8))(μ-H)]
  参考文献：
  名称：

  Synthesis, Reduction Chemistry, and Spectroscopic and Computational Studies of Isomeric Quinolinecarboxaldehyde Triosmium Clusters

  摘要：

  The quinoline derivatives Os-3(CO)(n)(mu(m)-eta(2)-L-H)(mu-H) (L = quinoline-4-carboxaldehyde, n 10, m = 2, 4; n = 9, N-C(8) bound, m = 3, 5; n = 10, N-C(2) bound, m = 2, 6; L = quinoline-3-carboxaldehyde, n = 9, N-C(8) bound, m = 3, 7) are obtained by the reaction of Os-3(CO)(10)(CH3CN)(2) with the quinoline-3-carboxaldehyde or -4-carboxaldehyde ligand followed by photochemical decarbonylation in the case of 5 and 7. The quinoline-4-carboxaldehyde clusters and the free ligand all show reversible 1e(-) reductions, but the electron-deficient 5 shows two separate reversible 1e(-) reductions, the first at much less negative potential than for the previously investigated Os-3(Co)(9)(mu(3)-eta(2) -L-H)(mu-H) (L = phenanthridine, 1; L = 5,6-benzoquinoline, 2), while the free ligand is reduced at a more negative potential than any of the clusters. The spectroscopic properties of the clusters upon electrochemical and chemical reduction have been investigated, and in the case of 4 selective line broadening of its H-1 NMR resonances is observed. Infrared spectrophotoelectrochemistry reveals that the CO stretching modes are shifted to lower frequencies, as expected. The pattern of unpaired spin densities in the reduced clusters predicted from the DFT calculations correlates with the observed selective line broadening, and EPR measurements confirm the formation of the radical anions at g values similar to those observed for pure organic radical anions.

  DOI：

  10.1021/om030564m

文献信息

• Selective covalent binding of a positively charged water-soluble benzoheterocycle triosmium cluster to single- and double-stranded DNA
  作者：Edward Rosenberg、Fabrizio Spada、Kent Sugden、Brooke Martin、Roberto Gobetto、Luciano Milone、Alessandra Viale

  DOI：10.1016/j.jorganchem.2004.08.044

  日期：2004.12

  )3I)3)] (4) was tested for its reactivity with plasmid DNA. In contrast to the band retardation previously observed with a related series of positively charged clusters, an intensification and retardation of three discrete bands was observed with increasing cluster concentration. In order to further investigate the apparent modification of DNA by 4, its interaction with a 22-oligomer (sequence 5′-AGT

  水溶性triosmium簇[O的3（CO）9（μ-η 2 - （4-CHO）C 9 H ^ 5 N）（μ-H）（P（OCH 2 CH 2 N（CH 3）3 I）3）]（4）测试了其与质粒DNA的反应性。与先前在一系列带正电的相关簇中观察到的谱带延迟相反，随着簇浓度的增加，观察到三个离散谱带的增强和延迟。为了进一步研究4对DNA的明显修饰，研究了其与22个寡聚物（序列5'-AGT TGT GGT GAC TTT CCC AGG C-3'）的相互作用。用该寡核苷酸（在Tris-HCl缓冲液和100 mM NaCl中的pH 7.4）孵育，然后进行HPLC分析，发现在寡核苷酸的三个位点形成了三种剂量依赖性产物，它们被指定为共价修饰。将4与32 P-ATP标记的寡核苷酸在5'末端孵育，然后用哌啶处理，并与标准的Maxam–Gilbert测序方案产品进行比较，结果仅显示了一般的背景裂解，表明修饰产物对