(6R,7S,Z)-methyl 7-(2-(5-chloro-2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)acetamido)-8-oxo-3-(pyridin-4-ylthio)-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | 1147849-89-5

• 英文名称: (6R,7S,Z)-methyl 7-(2-(5-chloro-2-(tritylamino)thiazol-4-yl)-2-(trityloxyimino)acetamido)-8-oxo-3-(pyridin-4-ylthio)-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 英文别名: methyl (6R,7S)-7-[[(2Z)-2-[5-chloro-2-(tritylamino)-1,3-thiazol-4-yl]-2-trityloxyiminoacetyl]amino]-8-oxo-3-pyridin-4-ylsulfanyl-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 1147849-89-5
• 化学式: C₅₇H₄₅ClN₆O₅S₂
• 分子量: 993.606
• InChiKey: JLLKPZXUVMRFOU-JDRUZNDXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  71
• 可旋转键数：
  17
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  189
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• CARBACEPHEM BETA-LACTAM ANTIBIOTICS
  申请人：Wagman Allan S.

  公开号：US20100267686A1

  公开（公告）日：2010-10-21

  Carbacephem β-lactam antibiotics having the following chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar 2 , R 1 , R 2 and R 3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
• US8445476B2
  申请人：——

  公开号：US8445476B2

  公开（公告）日：2013-05-21