[hydrido((S)-2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl)(α-picolylamino)(.etha.-1-tetrahydroborato)ruthenium(II)] | 857678-56-9

• 英文名称: [hydrido((S)-2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl)(α-picolylamino)(.etha.-1-tetrahydroborato)ruthenium(II)]
• 英文别名: RuH(η1-BH4)[(S)-tolbinap)](pica)
• CAS: 857678-56-9
• 化学式: C₅₄H₅₃BN₂P₂Ru
• 分子量: 903.857
• InChiKey: HGVSOMCJKIKQQA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  sodium tetrahydroborate 、 [dichloro((S)-2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl)(α-picolylamino)ruthenium(II)] 以 乙醇 、 苯 为溶剂， 生成 [hydrido((S)-2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl)(α-picolylamino)(.etha.-1-tetrahydroborato)ruthenium(II)]
  参考文献：
  名称：

  Asymmetric Hydrogenation of tert-Alkyl Ketones

  摘要：

  A combined system of RuCl2(tolbinap)(pica) and an alkaline or organic phosphazene base catalyzes asymmetric hydrogenation of sterically congested tert-alkyl ketones (TolBINAP = 2,2'-bis(di-4-tolylphosphino)-1,1'-binaphthyl, PICA = alpha-picolylamine). Hydrogenation with RuH(eta1-BH4)(tolbinap)(pica) does not require any strong base. Alcoholic solvents strongly affect the catalytic efficiency. The reaction proceeds smoothly in ethanol under 1-20 atm of H2 and at room temperature with a substrate to catalyst molar ratio of up to 100 000. Various aliphatic, aromatic, heteroaromatic, and olefinic tert-alkyl ketones are convertible to the corresponding chiral carbinols in high enantiomeric purity. Olefinic and heteroaromatic functions are left intact. Certain cyclic ketones are also usable. The mode of enantioface selection is consistent and predictable.

  DOI：

  10.1021/ja052071+