(S)-ferrocenyl(2-methyl-2-phenyl-2-sila-1-propyl)methylphosphine-P-borane | 1310457-40-9

• 英文名称: (S)-ferrocenyl(2-methyl-2-phenyl-2-sila-1-propyl)methylphosphine-P-borane
• CAS: 1310457-40-9
• 化学式: C₂₀H₂₈BFePSi
• 分子量: 394.16
• InChiKey: XRZSLQJOGIYYRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (S)-ferrocenyl(2-methyl-2-phenyl-2-sila-1-propyl)methylphosphine-P-borane 在 三乙烯二胺 作用下， 以 甲苯 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  将[RuCl 2（η 6 - p -cymene）（P *）]和将[RuCl 2（κ-P *-η 6 -arene）]配合物的P -Stereogenic膦。转移加氢中的活性以及与DNA的相互作用

  摘要：

  一系列半夹心钌络合物，将[RuCl的的制备2（η 6 - p（P * =（P *）-cymene）]小号-PMeRR'）和将[RuCl 2（κ-P *-η 6 - （芳烃）]，据报道含有P-立体生成的膦。通过添加（H 3 B）PMe 2 R（R = t -Bu （1），Cy（2），Fc（3））/秒获得硼烷保护的P-立体异构膦。-BuLi /（-）-天冬氨酸加成至苄基卤化物，羰基官能团和环氧化物的收率在40％至90％之间，ee值在70-99％范围内。那些含有芳基次要功能已在将[RuCl的制备中被使用2（η 6 - p复合物（P *）-cymene）]。除（H 3 B）PRMe（CH 2 SiMe 2 Ph）膦外，硼烷已使用HBF 4进行了脱保护，其中DABCO用于避免CH 2 -Si键的部分断裂。在（H 3 B）P（t -Bu）Me（CH 2 C（OH）Ph 2）（1l）获得脱水的膦。除了在

  DOI：

  10.1021/om3012294
• 作为产物：
  描述：

  ferrocenyldimethylphosphine-borane 、 苯基二甲基氯硅烷 在 (-)-sparteine 、 sec-butyllithium 作用下， 以 乙醚 为溶剂， 以90%的产率得到(S)-ferrocenyl(2-methyl-2-phenyl-2-sila-1-propyl)methylphosphine-P-borane
  参考文献：
  名称：

  P-Stereogenic monophosphines in Pd-catalysed enantioselective hydrovinylation of styrene

  摘要：

  Two groups of P-stereogenic monodentate phosphines containing pendant groups bearing functionalities capable of having secondary interactions, PArPhR (Ar = 2-[(2',6'-dimethoxy)-1,1'-biphenylyl] and R = OMe (6) or Me (8)) and PMeR(CH2R') (13, R t-Bu or 14 R Fc and R' SiMe3 (a), SiMe2Ph (b) or CH2(2-naphthyl) (c)) have been prepared in enantiomerically pure form by the Juge and Evans methodologies and characterised, including the crystal structure for the borane adduct of 12b. Reaction of the phosphines with the Pd dimer [Pd(eta(3)-2-Me-allyl)(mu-Cl)](2) produced neutral allylic complexes C [PdCl (eta(3)-2-Me-C3H4)P*], which have been characterised in solution and shown to be a mixture of isomers with different absolute configuration at the Pd atom. After abstraction of the chloride ligand by AgBF4, the solutions of cationic complexes have been used as catalyst precursors in the hydrovinylation of styrene under mild conditions. Very good activities (up to 1015 h(-1)), moderate to good selectivities to 3-phenyl-1-butene and low to moderate enantioselectivities (< 45% ee) have been found. Deep differences in the activity and enantioselectivity have been found depending on the structure of the ligand. In spite of that the results did not permit to confirm the improvement of the selectivities of the reaction by stabilization of the catalyst through secondary coordination with the potentially hemilabile ligands. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2011.02.034