a-chloro-dc-[2-(2'-pyridyl)phenyl-N',C]-b-(triphenylphosphine)palladium | 76857-95-9

• 英文名称: a-chloro-dc-[2-(2'-pyridyl)phenyl-N',C]-b-(triphenylphosphine)palladium
• 英文别名: [Pd(κ2-N,C-2-phenylpyridine)(triphenylphosphine)(Cl)]
• CAS: 76857-95-9
• 化学式: C₂₉H₂₃ClNPPd
• 分子量: 558.355
• InChiKey: ACGAXDHTBXRUSV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-苯基吡啶 以 氯仿 为溶剂， 生成 a-chloro-dc-[2-(2'-pyridyl)phenyl-N',C]-b-(triphenylphosphine)palladium
  参考文献：
  名称：

  NC palladacycles in the Heck arylation of ethylene: Synthesis, structure and their reactivity

  摘要：

  Monomeric cyclopalladated complexes with NC coordination using ligands 2-phenylpyridine, 2-phenylquinoline, 8-methylquinoline have been synthesized and the structures have been determined by single crystal X-ray structure analysis. The crystal structures of monomeric palladacycles prepared using benzophenone oxime, and 2-phenylpyridine have also been determined. The use of these complexes in the Heck arylation of ethylene with 2-bromo-6-methoxynaphthalne (BMN) to give 2-vinyl-6-methoxynapthalene which is an intermediate for the synthesis of anti-inflammatory drug Naproxen has been examined and also arylation of ethylene with 3-bromo-benzophenone and 4-bromo-isobutylbenzene was investigated. These palladacycles with NC coordination show excellent catalytic activity with a TOF > 4000 h (1). (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.11.065

文献信息

• In vitro and in vivo studies of neutral cyclometallated complexes against murine leukæmias
  作者：Gavin L Edwards、David St.C Black、Glen B Deacon、Laurence PG Wakelin

  DOI：10.1139/v05-109

  日期：2005.6.1

  Cyclometallated µ-halogeno dimers derived from nitrogen donor ligands (1-phenylpyrazoles, 2-phenylpyridine, and 1-(2′-pyridyl)indole) were treated with unidentate nitrogen and phosphorus donor ligands to give a series of neutral monomeric palladium(II) and platinum(II) complexes. An initial prescreen of the complexes against the mouse lymphoid leukæmia cell line L1210 indicated that the complexes exhibited growth inhibitory activity over a relatively wide concentration range. Two factors that gave rise to increased activity were steric hindrance about the metal centre resulting from hindered ligands such as 2,6-dimethylpyridine, or the presence of a phosphorus donor ligand. Little correlation between palladium and platinum complexes was noted. Four complexes were selected for further in vivo study and, while none of the palladium complexes showed more than marginal activity against P388 leukæmia at doses below toxic levels, one platinum complex with a hindered metal centre did display significant antitumour activity against this model.Key words: cyclometallation, palladium, platinum, cytotoxicity, anticancer.

  从氮配体（1-苯基吡唑，2-苯基吡啶和1-(2'-吡啶基)吲哚）衍生的环金属µ-卤代二聚体与一价氮和磷配体处理，形成了一系列中性单核钯(II)和铂(II)配合物。对这些配合物对小鼠淋巴细胞白血病细胞系L1210的初步筛选表明，这些配合物在相对宽的浓度范围内表现出生长抑制活性。导致增加活性的两个因素是金属中心周围的立体位阻，这是由于受阻配体（如2,6-二甲基吡啶）或磷配体的存在。钯和铂配合物之间几乎没有明显的相关性。选择了四种配合物进行进一步的体内研究，尽管在低于毒性水平的剂量下，没有一种钯配合物显示出对P388白血病的活性超过边缘水平，但一种金配合物，其金属中心受阻，确实显示出对这一模型的显著抗肿瘤活性。关键词：环金属化，钯，铂，细胞毒性，抗癌。
• Covalently cyclopalladium(II) complex/reduced-graphene oxide as the effective catalyst for the Suzuki–Miyaura reaction at room temperature
  作者：Roghayeh Hashemi Fath、S. Jafar Hoseini

  DOI：10.1016/j.jorganchem.2016.11.016

  日期：2017.1

  In this study, cyclometallated palladium complexes, [Pd(C-N)Cl(L)), in which CN = N(1), C(2')-chelated deprotonated 2-phenylpyridine, ppy, and L = dmso (dimethylsulfoxide) (complex 1) or PPh3 (complex 2), have been synthesized. Also, complex 1 attached to amine functionalized graphene oxide (1-f-GO) has been synthesized by covalently bonding of complex 1 onto the graphene oxide surface through coordination interaction with 3-(aminomethyl)pyridine ligand spacers. The supported catalyst showed enhanced catalytic performance towards Suzuki Miyaura reaction of aryl halides and phenylboronic acid at room temperature compared with the homogeneous analogues, and they could be readily recycled and reused several times without discernible loss of their activity. (C) 2016 Elsevier B.V. All rights reserved.