2-(2-chlorophenyl)-4,6-diferrocenyl-1-pyridin-2-yl-1,4-dihydropyrimidine | 1448535-97-4

• 英文名称: 2-(2-chlorophenyl)-4,6-diferrocenyl-1-pyridin-2-yl-1,4-dihydropyrimidine
• CAS: 1448535-97-4
• 化学式: C₃₅H₂₈ClFe₂N₃
• 分子量: 637.774
• InChiKey: VMBQDFWHQVLLAD-VTTXPQSASA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,3-diferrocenyl-2-propen-1-one 、 2-chloro-N-(pyridin-2-yl)benzimidamide 在 sodium 作用下， 以 异丙醇 为溶剂， 以65%的产率得到2-(2-chlorophenyl)-4,6-diferrocenyl-1-pyridin-2-yl-1,4-dihydropyrimidine
  参考文献：
  名称：

  Remarkable anti-breast cancer activity of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines

  摘要：

  A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of H-1 NMR, C-13 NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI(50) value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.04.021