(3-benzyloxy-5-chloro-phenyl)-acetic acid ethyl ester | 1182351-27-4

• 英文名称: (3-benzyloxy-5-chloro-phenyl)-acetic acid ethyl ester
• 英文别名: Ethyl 2-(3-chloro-5-phenylmethoxyphenyl)acetate
• CAS: 1182351-27-4
• 化学式: C₁₇H₁₇ClO₃
• 分子量: 304.773
• InChiKey: POWZTMZEEDYPPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：HUTCHINSON John Howard

  公开号：US20120058123A1

  公开（公告）日：2012-03-08

  Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD 2 receptors. Also described herein are methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

  本文描述了一些PGD2受体拮抗剂化合物。还描述了包括这些PGD2受体拮抗剂化合物的药物组合物和药物。此外，还描述了使用这些PGD2受体拮抗剂，单独或与其他化合物联合治疗呼吸系统、心血管系统和其他PGD2依赖性或PGD2介导的疾病或病症的方法。
• CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：Hutchinson John Howard

  公开号：US20110098302A1

  公开（公告）日：2011-04-28

  Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD 2 receptors described herein, as well as methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

  本文描述了PGD2受体拮抗剂化合物。还描述了包括本文所述的PGD2受体拮抗剂在内的制药组合物和药物，以及使用这种PGD2受体拮抗剂，单独或与其他化合物结合，治疗呼吸系统、心血管系统和其他PGD2依赖性或PGD2介导的疾病或病症的方法。
• US8067445B2
  申请人：——

  公开号：US8067445B2

  公开（公告）日：2011-11-29
• US8242145B2
  申请人：——

  公开号：US8242145B2

  公开（公告）日：2012-08-14
• US8362044B2
  申请人：——

  公开号：US8362044B2

  公开（公告）日：2013-01-29