(2S)-2-(hexanoylamino)-3-({2-hydroxy-4-[2-(1,4,5,6-tetrahydropyrimidin-2-ylamino)ethoxy]benzoyl}amino)propanoic acid | 247124-50-1

• 英文名称: (2S)-2-(hexanoylamino)-3-({2-hydroxy-4-[2-(1,4,5,6-tetrahydropyrimidin-2-ylamino)ethoxy]benzoyl}amino)propanoic acid
• 英文别名: (2S)-2-(hexanoylamino)-3-[[2-hydroxy-4-[2-(1,4,5,6-tetrahydropyrimidin-2-ylamino)ethoxy]benzoyl]amino]propanoic acid
• CAS: 247124-50-1
• 化学式: C₂₂H₃₃N₅O₆
• 分子量: 463.534
• InChiKey: KBTMSIRCHVSIGL-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  161
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Acylresorcinol derivatives are selective vitronectin receptor inhibitors
  申请人：American Home Products Corporation

  公开号：US20030186967A1

  公开（公告）日：2003-10-02

  Compounds of the formula 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are as defined in the specification are useful in the treatment of various disorders including, but not limited to, cancer, angiogenesis, restenosis, inflammation, bone diseases, and as antiviral agents.

  式1中，R1、R2、R3、R4、R5和n的定义如说明书所述，这些化合物可用于治疗各种疾病，包括但不限于癌症、血管生成、再狭窄、炎症、骨病和作为抗病毒剂。
• [EN] ACYLRESORCINOL DERIVATIVES AS SELECTIVE VITRONECTIN RECEPTOR INHIBITORS<br/>[FR] DERIVES D'ACYLRESORCINOL INHIBITEURS SELECTIFS DE LA VITRONECTINE
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：WO1999052879A1

  公开（公告）日：1999-10-21

  (EN) Compounds of formula (I) are useful in the treatment of various disorders including, but not limited to, cancer, angiogenesis, restenosis, inflammation, bone diseases, and as antiviral agents. Novel methods of makings compounds of formula (I) are also provided.(FR) L'invention porte sur des composés de formule (I) servant, au traitement de différents troubles dont, non limitativement, le cancer, l'angiogénèse, les resténoses, les inflammations, et les maladies de l'os, et d'agent antiviral. L'invention porte également sur de nouvelles méthodes d'obtention desdits composés.