4-{3-[4-(3-{4-[amino(isopropoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}-N'-(isopropoxycarbonyl)benzamidine | 943150-83-2

• 英文名称: 4-{3-[4-(3-{4-[amino(isopropoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}-N'-(isopropoxycarbonyl)benzamidine
• 英文别名: propan-2-yl N-[4-[3-[1-[3-[4-(N-propan-2-yloxycarbonylcarbamimidoyl)phenoxy]propyl]piperidin-4-yl]propoxy]benzenecarboximidoyl]carbamate
• CAS: 943150-83-2
• 化学式: C₃₃H₄₇N₅O₆
• 分子量: 609.766
• InChiKey: BZMBWEDRPJFGEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  151
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• NOVEL ARYLAMIDINE DERIVATIVE, SALT THEREOF AND ANTIFUNGAL AGENT CONTAINING THOSE
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1967190B1

  公开（公告）日：2010-08-04
• PHARMACEUTICAL COMPOSITION COMPRISING PHENYLAMIDINE DERIVATIVE AND METHOD OF USING THE PHARMACEUTICAL COMPOSITION IN COMBINATION WITH ANTIFUNGAL AGENT
  申请人：Nishikawa Hiroshi

  公开号：US20100098750A1

  公开（公告）日：2010-04-22

  A pharmaceutical composition comprising a phenylamidine derivative or a salt thereof, represented by a general formula, wherein R 1 and R 2 may be same or different, and represent an optionally substituted C 3-4 alkyl group; and one or more agents selected from azole antifungal agents, polyene antifungal agents, candin antifungal agents and fluoropyrimidine antifungal agents, and a method for combination use of the phenylamidine derivative or a salt thereof and the agents are useful for treating fungal infections caused by a fungal pathogen.
• US8173157B2
  申请人：——

  公开号：US8173157B2

  公开（公告）日：2012-05-08
• US8536343B2
  申请人：——

  公开号：US8536343B2

  公开（公告）日：2013-09-17