1-丙-2-炔基-环辛醇 | 69984-37-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-丙-2-炔基-环辛醇
• 英文名称: 1-(2-Propinyl)cyclooctanol
• 英文别名: 1-prop-2-ynyl-cyclooctanol；1-Prop-2-inyl-cyclooctanol；1-Prop-2-ynylcyclooctan-1-ol
• CAS: 69984-37-8
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: WRKBFCMWVAPDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-丙-2-炔基-环辛醇 生成 carbamic acid-(1-prop-2-ynyl-cyclooctyl ester)
  参考文献：
  名称：

  The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep

  摘要：

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.

  DOI：

  10.1080/08964280109595773
• 作为产物：
  描述：

  环辛酮 、 allenylmagnesium bromide 以 乙醚 为溶剂， 生成 1-丙-2-炔基-环辛醇
  参考文献：
  名称：

  A New Synthesis of γ-Butyrolactones via AuCl₃- or Hg(II)-Catalyzed Intramolecular Hydroalkoxylation of 4-Bromo-3-yn-1-ols

  摘要：

  An efficient conversion of 4-bromo-3-yn-1-ols to gamma-butyrolactones via AuCl3-catalyzed electrophilic cyclization (hydroxyl-assisted regioselective hydration) in wet toluene is described. Various secondary and tertiary alcohols including benzylic systems were found to be equally reactive with moderate to excellent yields obtained in all cases.

  DOI：

  10.1021/ol2033493

文献信息

• Gaude,D. et al., Bulletin de la Societe Chimique de France, 1977, p. 758 - 764
  作者：Gaude,D. et al.

  DOI：——

  日期：——