4-chloro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline | 1610610-21-3

• 英文名称: 4-chloro-N-methyl-N-((3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)methyl)aniline
• 英文别名: 4-chloro-N-methyl-N-[[3-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyridin-5-yl]methyl]aniline
• CAS: 1610610-21-3
• 化学式: C₂₂H₁₇ClF₃N₃
• 分子量: 415.845
• InChiKey: MKWHZSORVFXAAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRM LLC

  公开号：WO2014078802A1

  公开（公告）日：2014-05-22

  The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了化合物的公式I：[在此插入公式]或其药学上可接受的盐、互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的药物组合物以及使用这种化合物用于治疗、预防、抑制、改善或根除由疟原虫引起的疾病的病理学和/或症状学的方法，例如疟疾。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：Chatterjee Arnab Kumar

  公开号：US20140155367A1

  公开（公告）日：2014-06-05

  The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了式I的化合物：或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的制药组合物以及使用这种化合物治疗、预防、抑制、改善或根除由疟原虫（如疟疾）引起的病理和/或症状的方法。
• Method for the Synthesis of Diacids or Diesters from Natural Fatty Acids and/or Esters
  申请人：Arkema France

  公开号：US20140155647A1

  公开（公告）日：2014-06-05

  Disclosed herein a process for the synthesis of diacids or diesters of general formula ROOC—(CH 2 )x-COOR, in which n represents an integer between 5 and 14 and R is either H or an alkyl radical of 1 to 4 carbon atoms, starting from long-chain natural monounsaturated fatty acids or esters comprising at least 10 adjacent carbon atoms per molecule, of formula CH 3 —(CH 2 )n-CHR 1 —CH 2 —CH═CH—(CH 2 )p-COOR, in which R represents H or an alkyl radical comprising from 1 to 4 carbon atoms, R 1 is either H or OH, and n and p, which are identical or different, are indices between 2 and 11.

  本文公开了一种合成通式为ROOC—(CH2)x-COOR的二酸或二酯的方法，其中n表示5到14之间的整数，R为H或1至4个碳原子的烷基基团，起始于长链天然单不饱和脂肪酸或酯，每个分子至少包含10个相邻的碳原子，通式为CH3—( )n-CHR1— —CH═CH—( )p-COOR，其中R表示H或含有1至4个碳原子的烷基基团，R1为H或OH，n和p是相同或不同的指数，介于2和11之间。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS
  申请人：Novartis AG

  公开号：EP3405468A1

  公开（公告）日：2018-11-28
• US8871754B2
  申请人：——

  公开号：US8871754B2

  公开（公告）日：2014-10-28