[CuCl2(L)] | 1422006-25-4

• 英文名称: [CuCl2(L)]
• CAS: 1422006-25-4
• 化学式: C₇H₉Cl₂CuN₃O₃
• 分子量: 317.619
• InChiKey: LVQPRWMIJXJQTI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 2-(N-methylamino)-3-methyl-4-nitropyridine N-oxide 以 乙醇 为溶剂， 反应 0.25h， 生成 [CuCl2(L)]
  参考文献：
  名称：

  Structure–activity relationship disturbed by a solvolytic process: Study on the [Cu(II)-4-nitropyridine N-oxide derivative] system

  摘要：

  The chelate complex [CuCl2(L)] where L = 2-methylamino-3-methyl-4-nitropyridine-N-oxide has been obtained and characterized, both physicochemically (by the X-ray structure analysis of the complex and the ligand, FTIR, EPR and electronic spectroscopy, and thermal analysis) and cytotoxically (MCF-7, A549, SW707, P388, Balb3T3). In solution, atypically for chelate complexes, it undergoes rapid solvolysis forming various 6- (or 5) and 4-coordinate species, depending upon the solvent. Such rapid decomposition may indicate a catalytic effect of the copper operating in the system. However, the cytotoxic activity in solution for the new copper chelate complex appeared to be a surprisingly low. Thus, before drawing any conclusions on the structure-activity relationship, one must carefully check the chemical identity of the compound(s) in both phases. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.09.060