dimethyl-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenylphosphoniteborane | 1337878-55-3

• 英文名称: dimethyl-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenylphosphoniteborane
• CAS: 1337878-55-3
• 化学式: C₁₅H₂₈BO₆P
• 分子量: 346.168
• InChiKey: WJGWCXRHDXYPED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  dimethyl-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenylphosphoniteborane 在 三乙烯二胺 作用下， 以 苯 为溶剂， 反应 22.0h， 以67%的产率得到dimethyl 3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenylphosphonite
  参考文献：
  名称：

  Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

  摘要：

  Site-specific functionalization of proteins by bloorthogonal modification offers a convenient pathway to create, modify, and study biologically active biopolymers. In this paper the Staudinger reaction of aryl-phosphonites for the chemoselective functionalization of azido-peptides and proteins was probed. Different water-soluble phosphonites with ollgoethylene substituents were synthesized and reacted with unprotected azido-containing peptides in aqueous systems at room temperature in high conversions. Finally, the Staudinger-phosphonite reaction was successfully applied to the site-specific modification of the protein calmodulin.

  DOI：

  10.1021/ol2020175
• 作为产物：
  描述：

  dimethyl 3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenylphosphonite 在 dimethyl sulfide borane 作用下， 以 乙醚 为溶剂， 反应 15.0h， 以3.6958 g的产率得到dimethyl-3-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)phenylphosphoniteborane
  参考文献：
  名称：

  Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins

  摘要：

  Site-specific functionalization of proteins by bloorthogonal modification offers a convenient pathway to create, modify, and study biologically active biopolymers. In this paper the Staudinger reaction of aryl-phosphonites for the chemoselective functionalization of azido-peptides and proteins was probed. Different water-soluble phosphonites with ollgoethylene substituents were synthesized and reacted with unprotected azido-containing peptides in aqueous systems at room temperature in high conversions. Finally, the Staudinger-phosphonite reaction was successfully applied to the site-specific modification of the protein calmodulin.

  DOI：

  10.1021/ol2020175