| 192118-70-0

• CAS: 192118-70-0
• 化学式: BF₄*C₁₀H₂₀ReS₆
• 分子量: 605.676
• InChiKey: DCGWLPWQBCIFSG-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  在 L-ascorbic acid 作用下， 以 水 为溶剂， 以86%的产率得到
  参考文献：
  名称：

  Electron Transfer Induced CS Bond Cleavage in Rhenium and Technetium Thioether Complexes: Structural and Chemical Evidence forπ Back-Donation to CSσ* Orbitals

  摘要：

  The trends in carbon‐sulfur bond length for complexes of 1,4,7‐trithiacyclononane (9S3) provide compelling evidence that CS σ* orbitals accept π‐electron density from the metal. As the metal d‐orbital energy and occupancy increase, this leads ultimately to cleavage of the CS bonds with concomitant release of ethene in the Re and Tc complexes [Eq. (a)]. equation image

  DOI：

  10.1002/anie.199712051

文献信息

• Trithiacyclononane as a Ligand for Potential Technetium and Rhenium Radiopharmaceuticals:  Synthesis of [M(9S3)(SC₂H₄SC₂H₄S)][BF₄] (M = ⁹⁹Tc, Re, ¹⁸⁸Re) via C−S Bond Cleavage
  作者：Gregory E. D. Mullen、Philip J. Blower、Daniel J. Price、Anne K. Powell、Mark J. Howard、Michael J. Went

  DOI：10.1021/ic991240m

  日期：2000.9.1

  Chemical or electrochemical reduction of the 1,4,7-trithiacyclononane (9S3) complexes [M-II(9S3)(2)][BF4](2) (M = Re (3a) or Tc (3b)) results in instantaneous C-S bond cleavage to yield ethene and the stable M-III thiolate complexes [M-III(9S3)L][BF4] (hl = Re (4a) or Tc (4b), L = SCH2CH2SCH2CH2S). Compounds 4 have been characterized by H-1 NMR spectroscopy, and the pseudo-octahedral geometry of 4b has been confirmed by X-ray crystallography. Upon electrochemical reduction 4a loses ethene, while 3b can be reversibly reduced to [Tc-II(9S3)L], which is then further reduced to Tc(I) with loss of ethene. Successive ethene loss is observed in the mass spectra of compounds 3 and 4. The radiosynthesis of 4a with Re-188 can be comfortably completed within 10 min starting with (ReO4-)-Re-188 from a W-188/Re-188 generator, with a radiochemical yield in excess of 90%. and thus represents a practical approach to the preparation of stable Re-188 (and Tc-99m) thioether co lex derivatives/conjugates for clinical use. Crystal data: 4b, C10H20S6Tc, orthorhombic Pbca, a = 12.233(2) b = 14.341(2) Angstrom, c = 20.726(3) Angstrom, Z = 8.