| 1332367-20-0

• CAS: 1332367-20-0
• 化学式: C₂₃H₂₁GaN₅O₆
• 分子量: 531.45
• InChiKey: UNVGYERDMKXHTJ-HNAZWQGWSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  氢化镓 、 2-(p-nitrobenzyl)-1,2-[N,N'-(p-nitrobenzyl)methyl]-N,N'-bis-[6-carboxy-2-pyridylmethyl]ethylenediamine 在 NaOCOCH₃ 作用下， 以 盐酸 为溶剂， 以98%的产率得到
  参考文献：
  名称：

  Acyclic Chelate with Ideal Properties for ⁶⁸Ga PET Imaging Agent Elaboration

  摘要：

  We have investigated novel bifunctional chelate alternatives to the aminocarboxylate macrocycles NOTA (N3O3) or DOTA (N4O4) for application of radioisotopes of Ga to diagnostic nuclear medicine and have found that the linear N4O2 chelate H(2)dedpa coordinates Ga-67 quantitatively to form [Ga-67(dedpa)](+) after 10 min at RT. Concentration-dependent coordination to H(2)dedpa of either Ga-68 or Ga-67 showed quantitative conversion to the desired products with ligand concentrations as low as 10(-7) M. With Ga-68, specific activities as high as 9.8 mCi nmol(-1) were obtained without purification. In a 2 h competition experiment against human apo-transferrin, [Ga-67(dedpa)](+) showed no decomposition. Two bifunctional versions of H(2)dedpa are also described, and these both coordinate to Ga-67 at RT within 10 min. Complete syntheses, characterizations, labeling studies, and biodistribution profiles of the Ga-67 complexes are presented for the new platform chelates. The stability of these platform chelates is higher than that of DOTA.

  DOI：

  10.1021/ja106399h