2-(3- chlorophenoxy)propan-1-amine | 6440-95-5

• 英文名称: 2-(3- chlorophenoxy)propan-1-amine
• 英文别名: 2-(3-Chloro-phenoxy)-propylamine；2-(3-chlorophenoxy)propan-1-amine
• CAS: 6440-95-5
• 化学式: C₉H₁₂ClNO
• mdl: MFCD07374144
• 分子量: 185.653
• InChiKey: OQUPPUVKQSGOEL-UHFFFAOYSA-N

物化性质

• 沸点：
  277.3±20.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3- chlorophenoxy)propan-1-amine 、 苯胺基乙腈 生成 2-anilino-N'-[2-(3-chlorophenoxy)propyl]ethanimidamide
  参考文献：
  名称：

  HODSON, H. F.

  摘要：

  DOI：

文献信息

• IMINOPYRIDINE DERIVATIVE AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2077262A1

  公开（公告）日：2009-07-08

  Provided are an iminopyridine derivative having a selective α1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an α1D adrenergic receptor antagonistic action. An α1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an α1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

  提供了一种具有选择性α1D肾上腺素能受体拮抗作用的咪唑吡啶衍生物，可用作预防或治疗下尿路疾病等药物，以及一种筛选具有α1D肾上腺素能受体拮抗作用的化合物的方法。该α1D肾上腺素能受体拮抗剂包含由下式表示的化合物或其盐：其中，每个符号如规范中所定义。该方法包括测量具有膀胱出口梗阻的大鼠膀胱平滑肌张力的药物，用于预防或治疗下尿路疾病的α1D肾上腺素能受体拮抗剂的筛选方法。
• Iminopyridine Derivative and Use Thereof
  申请人：Yoshida Masato

  公开号：US20100016315A1

  公开（公告）日：2010-01-21

  Provided are an iminopyridine derivative having a selective α 1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an α 1D adrenergic receptor antagonistic action. An α 1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an α 1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

  提供了一种具有选择性α1D肾上腺素受体拮抗作用的咪唑吡啶衍生物，可用作预防或治疗下尿路疾病等药物，以及一种筛选具有α1D肾上腺素受体拮抗作用的化合物的方法。一种含有以下式子所表示的化合物或其盐的α1D肾上腺素受体拮抗剂：其中每个符号如规范中所定义，以及一种筛选用于预防或治疗下尿路疾病的具有α1D肾上腺素受体拮抗作用的药物的方法，该方法包括测量具有膀胱出口梗阻的大鼠膀胱平滑肌张力。
• Iminopyridine derivative and use thereof
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2535330A2

  公开（公告）日：2012-12-19

  A screening method for an agent having an α1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which comprises measuring the tension of the bladder smooth muscle of a bladder outlet obstruction rat.

  一种具有α1D肾上腺素能受体拮抗作用的预防或治疗下尿路疾病药物的筛选方法，包括测量膀胱出口梗阻大鼠膀胱平滑肌的张力。
• US8470859B2
  申请人：——

  公开号：US8470859B2

  公开（公告）日：2013-06-25
• [EN] COMBINATIONS OF PERIPHERAL 5-HT2A RECEPTOR ANTAGONISTS AND CENTRAL 5-HT2A RECEPTOR AGONISTS<br/>[FR] COMBINAISONS D'ANTAGONISTES DU RÉCEPTEUR 5-HT2A PÉRIPHÉRIQUE ET D'AGONISTES DU RÉCEPTEUR 5-HT2A CENTRAL
  申请人：[en]GILGAMESH PHARMACEUTICALS, INC.

  公开号：WO2023028086A1

  公开（公告）日：2023-03-02

  Methods of treating mood disorders with compounds disclosed herein. Also provided are pharmaceutical compositions that include those compounds.