1-(2-Ethoxy-phenoxy)-3-(2-hydroxy-ethylamino)-propan-2-ol | 35609-87-1

• 英文名称: 1-(2-Ethoxy-phenoxy)-3-(2-hydroxy-ethylamino)-propan-2-ol
• 英文别名: 1-(2-Ethoxyphenoxy)-3-(2-hydroxyethylamino)propan-2-ol
• CAS: 35609-87-1
• 化学式: C₁₃H₂₁NO₄
• 分子量: 255.314
• InChiKey: UPXHLKRBAYAGIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  71
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] METHODS FOR PRODUCING VILOXAZINE SALTS AND NOVEL POLYMORPHS THEREOF<br/>[FR] PROCÉDÉS DE FABRICATION DE SELS DE VILOXAZINE ET LEURS NOUVEAUX POLYMORPHES
  申请人：SUPERNUS PHARMACEUTICALS INC

  公开号：WO2011130194A2

  公开（公告）日：2011-10-20

  Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HC1 while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.