3-chloro-8-methoxy-11H-indolo<3,2-c>quinoline hydrochloride | 116792-16-6

• 英文名称: 3-chloro-8-methoxy-11H-indolo<3,2-c>quinoline hydrochloride
• 英文别名: 3-chloro-8-methoxy-11H-indolo[3,2-c]quinoline hydrochloride；3-chloro-8-methoxy-11H-indolo[3,2-c]quinoline;hydrochloride
• CAS: 116792-16-6
• 化学式: C₁₆H₁₁ClN₂O*ClH
• 分子量: 319.19
• InChiKey: KGNGJSKLRZKMLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.95
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  37.91
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  7-氯-2,3-二氢喹啉-4-酮 、 (4-甲氧基苯基)肼 以68%的产率得到3-chloro-8-methoxy-11H-indolo<3,2-c>quinoline hydrochloride
  参考文献：
  名称：

  Synthesis and in vitro antimalarial activity of some indolo[3,2-c]quinolines

  摘要：

  A series of indolo]3,2-c]quinolines (1b-e) was synthesized by Fischer indolization of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one with the appropriate hydrazines (7b-e). Evaluation of in vitro antimalarial activity was carried out against a chloroquine resistant strain of Plasmodium falciparum. Except for compound 1e which lacked a basic side chain at position 9, the other indolo[3,2-c]quinolines 1b-d were active. The most active compound was 3-chloro-8-methoxy-9-(4-methyl-1-piperazinylmethyl)-11H-indolo[3,2-c]quinoline (1d) trihydrochloride which was about 10(4) times more active than chloroquine in vitro. The effects of structural variation on antimalarial activity were discussed.

  DOI：

  10.1016/0223-5234(92)90152-q

文献信息

• IBRAHIM, EL-SAYED;MONTGOMERIE, ANITA M.;SNEDDON, ANDREW H.;PROCTOR, GEORG+, EUR. J. MED. CHEM., 23,(1988) N 2, 183-188
  作者：IBRAHIM, EL-SAYED、MONTGOMERIE, ANITA M.、SNEDDON, ANDREW H.、PROCTOR, GEORG+

  DOI：——

  日期：——