cis-[PtCl2(NH=C(Et)N=C(NMe2)2)2] | 931100-59-3

• 英文名称: cis-[PtCl2(NH=C(Et)N=C(NMe2)2)2]
• CAS: 931100-59-3；930770-59-5
• 化学式: C₁₆H₃₆Cl₂N₈Pt
• 分子量: 606.501
• InChiKey: CNMYQPMFYWBZTR-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  cis-[PtCl2(NH=C(Et)N=C(NMe2)2)2] 以 further solvent(s) 为溶剂， 生成 trans-[PtCl₂(NH=C(Et)N=C(NMe₂)2)2]
  参考文献：
  名称：

  Pt^II-Mediated Nitrile−Tetramethylguanidine Coupling as a Key Step for a Novel Synthesis of 1,6-Dihydro-1,3,5-triazines

  摘要：

  The coupling between tetramethylguanidine, HNC(NMe2)(2), and coordinated organonitriles in the platinum(II) complexes cis/trans-[PtCl2(RCN)(2)] (R = Me, Et, Ph) proceeds rapidly under mild conditions to afford the diimino compounds containing two N-bound monodentate 1,3-diaza-1,3-diene ligands [PtCl2{NHC(R)NC(NMe2)(2)}(2)] (R = Et, trans-1; R = Ph, trans-2; R = Me, cis-3; R = Et, cis-4), and this reaction is the first observation of metal-mediated nucleophilic addition of a guanidine to ligated nitrile. Complexes 1-4 were characterized by elemental analyses (C, H, N), X-ray diffraction, FAB mass spectrometry, IR, and H-1 and C-13{H-1} NMR spectroscopies; assignment of signals from E/Z-forms of 1,3-diaza-1,3-diene ligands and verification of routes for their Z -><- E isomerization in solution were performed using 2D H-1,H-1-COSY, H-1,C-13-HETCOR, and 1D NOE NMR experiments. The newly formed and previously unknown 1,3-diaza-1,3-dienes NHC(R)NC(NMe2)(2) were liberated from the platinum(II) complexes [PtCl2{NHC(R)NC(NMe2)(2)}(2)] (1-3) by substitution with 2 equiv of 1,2-bis-(diphenylphosphino)ethane (dppe) to give the uncomplexed HNC(R)NC(NMe2)(2) species (5-7) in solution and the solid [Pt(dppe)(2)](Cl)(2). The former were utilized in situ, after filtration of the latter, in the reaction with 1,3-di-p-tolylcarbodiimide, (p-tol)NCN(tol-p), in CDCl3 to generate (6E)-N,N-dimethyl-1-(4-methylphenyl)-6-[(4-methylphenyl)imino]-1,6-dihydro-1,3,5-triazin-2-amines) (8-10) due to the [4 + 2]-cycloaddition accompanying elimination of HNMe2. The formulation of 8-10 is based on ESI-MS, H-1, C-13{H-1} NMR, and X-ray crystal structures determined for 9 and 10. The reaction of 1,3-diaza-1,3-dienes with 1,3-di-p-tolylcarbodiimide, described in this article, constitutes a novel synthetic approach to a useful class of heterocyclic species like 1,6-dihydro-1,3,5-triazines.

  DOI：

  10.1021/ic061884b
• 作为产物：
  描述：

  四甲基胍 以 further solvent(s) 为溶剂， 生成 cis-[PtCl2(NH=C(Et)N=C(NMe2)2)2]
  参考文献：
  名称：

  Pt^II-Mediated Nitrile−Tetramethylguanidine Coupling as a Key Step for a Novel Synthesis of 1,6-Dihydro-1,3,5-triazines

  摘要：

  The coupling between tetramethylguanidine, HNC(NMe2)(2), and coordinated organonitriles in the platinum(II) complexes cis/trans-[PtCl2(RCN)(2)] (R = Me, Et, Ph) proceeds rapidly under mild conditions to afford the diimino compounds containing two N-bound monodentate 1,3-diaza-1,3-diene ligands [PtCl2{NHC(R)NC(NMe2)(2)}(2)] (R = Et, trans-1; R = Ph, trans-2; R = Me, cis-3; R = Et, cis-4), and this reaction is the first observation of metal-mediated nucleophilic addition of a guanidine to ligated nitrile. Complexes 1-4 were characterized by elemental analyses (C, H, N), X-ray diffraction, FAB mass spectrometry, IR, and H-1 and C-13{H-1} NMR spectroscopies; assignment of signals from E/Z-forms of 1,3-diaza-1,3-diene ligands and verification of routes for their Z -><- E isomerization in solution were performed using 2D H-1,H-1-COSY, H-1,C-13-HETCOR, and 1D NOE NMR experiments. The newly formed and previously unknown 1,3-diaza-1,3-dienes NHC(R)NC(NMe2)(2) were liberated from the platinum(II) complexes [PtCl2{NHC(R)NC(NMe2)(2)}(2)] (1-3) by substitution with 2 equiv of 1,2-bis-(diphenylphosphino)ethane (dppe) to give the uncomplexed HNC(R)NC(NMe2)(2) species (5-7) in solution and the solid [Pt(dppe)(2)](Cl)(2). The former were utilized in situ, after filtration of the latter, in the reaction with 1,3-di-p-tolylcarbodiimide, (p-tol)NCN(tol-p), in CDCl3 to generate (6E)-N,N-dimethyl-1-(4-methylphenyl)-6-[(4-methylphenyl)imino]-1,6-dihydro-1,3,5-triazin-2-amines) (8-10) due to the [4 + 2]-cycloaddition accompanying elimination of HNMe2. The formulation of 8-10 is based on ESI-MS, H-1, C-13{H-1} NMR, and X-ray crystal structures determined for 9 and 10. The reaction of 1,3-diaza-1,3-dienes with 1,3-di-p-tolylcarbodiimide, described in this article, constitutes a novel synthetic approach to a useful class of heterocyclic species like 1,6-dihydro-1,3,5-triazines.

  DOI：

  10.1021/ic061884b