chloro(ethylenediamine)[3-(methylsulfinyl)propanoato-S]platinum(II) | 162054-01-5

• 英文名称: chloro(ethylenediamine)[3-(methylsulfinyl)propanoato-S]platinum(II)
• CAS: 162054-01-5
• 化学式: C₆H₁₅ClN₂O₃PtS
• 分子量: 425.796
• InChiKey: AFQWODYIGUMEAY-VFIYQRISSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [Pt(ethylenediamine)(3-(methylsulfinyl)propanoato)]NO3 在 sodium chloride 作用下， 以 水 为溶剂， 生成 chloro(ethylenediamine)[3-(methylsulfinyl)propanoato-S]platinum(II)
  参考文献：
  名称：

  Cisplatin analogues with sulfur donor ligands. (Ethylenediamine)platinum(II) complexes with ligands possessing a sulfinyl or sulfanyl group linked to an anionic oxygen donor atom. Reactivity and cytotoxicity

  摘要：

  Complexes of formula [Pt(en)L]NO3, where en = ethylenediamine and L is a ligand in which a methylsulfinyl or methylsulfanyl group is linked to a carboxylate or phenolate moiety, have been synthesized and characterized by spectroscopic techniques. The ligand L is chelated to Pt via the sulfur and anionic oxygen atoms. The reactivities of these complexes towards nucleophiles [Nu = Cl- or guanosine 5'-monophosphate(2-), GMP] have been investigated by H-1 NMR spectroscopy; GMP is more reactive than Cl-. The Pt-O bonds react more readily than the Pt-S bonds and, depending on the nature of L and Nu, the reactions either stop at the monosubstituted complex [Pt(en)L(Nu)] (with L monodentate and co-ordinated to Pt via the sulfur atom), or yield [Pt(en)(Nu)2]. The complex with L = 2-(methylsulfanyl)phenolate is unreactive. The stable monosubstituted products have been characterized. There is little correlation between the rates and the modes of reactivity of complexes [Pt(en)L]NO3 towards GMP and their cytotoxicities against the human ovarian carcinoma A2780 cell line.

  DOI：

  10.1039/dt9950000579