1-(4-chlorophenyl)-2-(4-piperidinyl)ethanone hydrochloride | 78056-66-3

• 英文名称: 1-(4-chlorophenyl)-2-(4-piperidinyl)ethanone hydrochloride
• 英文别名: 1-(4-Chlorophenyl)-2-piperidin-4-ylethanone;hydrochloride
• CAS: 78056-66-3
• 化学式: C₁₃H₁₆ClNO*ClH
• 分子量: 274.19
• InChiKey: KQMCCBGGPVRNBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.33
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Novel 1,3-dihydro-1-((1-piperidinyl)alkyl)-2H-benzimidazol-2-one derivatives
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0037713A1

  公开（公告）日：1981-10-14

  1,3-dihydro-1-[(1-piperidinyl)alkyl]- 2H-benzimidazol-2-one derivatives of the formula wherein R1 and R2 are each independently selected from the group consisting of hydrogen, halo, lower alkyl and trifluoromethyl; R3 is a member selected from the group consisting of hydrogen, lower alkyl and lower alkylcarbonyl; lk is a lower alkylene radical; R4 and R5 are each independently selected from the group consisting of hydrogen and lower alkyl; X is a member selected from the group consisting of wherein said R2 is hydrogen or lower alkyl and said q is the integer 2 or 3; and Ar is a member selected from the group consisting of phenyl, substituted phenyl, pyridinyl and thienyl, wherein said substituted phenyl has from 1 to 3 substituents each independently selected from the group consisting of halo, lower alkyl, lower alkyloxy, amino, nitro and trifluoromethyl, which compounds are potent serotonin-antagonists and central nervous system depressants having a capability as antiemetic neuroleptic and anti-congestive agents.

  式中的 1,3-二氢-1-[(1-哌啶基)烷基]-2H-苯并咪唑-2-酮衍生物 其中 R1 和 R2 各自独立地选自氢、卤素、低级烷基和三氟甲基组成的组； R3 是选自由氢、低级烷基和低级烷基羰基组成的组； lk 是低级亚烷基； R4 和 R5 各自独立地选自氢和低级烷基组成的组； X 选自以下组成的组 其中所述 R2 为氢或低级烷基，所述 q 为整数 2 或 3；以及 Ar 是选自由苯基、取代苯基、吡啶基和噻吩基组成的组，其中所述取代苯基具有 1 至 3 个各自独立选自由卤代、低级烷基、低级烷氧基、氨基、硝基和三氟甲基组成的组的取代基、 这些化合物是强效的血清素拮抗剂和中枢神经系统抑制剂，具有止吐、神经安定和抗充血作用。
• US4254127A
  申请人：——

  公开号：US4254127A

  公开（公告）日：1981-03-03