[(N-ethylpiperazinedithiocarbamate)Au₂Cl₅] | 1428789-08-5

• 英文名称: [(N-ethylpiperazinedithiocarbamate)Au₂Cl₅]
• 英文别名: [(EtPizDTC)Au₂Cl₅]
• CAS: 1428789-08-5
• 化学式: C₇H₁₃Au₂Cl₅N₂S₂
• 分子量: 760.524
• InChiKey: GKIGKOPCEDJCRG-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  sodium 4-ethylpiperazine-1-carbodithioate 、 potassium tetrachloroaurate(III) dihydrate 以 水 为溶剂， 反应 2.0h， 以56.3%的产率得到[(N-ethylpiperazinedithiocarbamate)Au₂Cl₅]
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity of the Au(III) complexes with cyclic amine-based dithiocarbamate ligands

  摘要：

  Seven new Au(III) complexes ([(PipDTC)AuCl2] (1), [(MoDTC)AuCl2] (2), [(BzoPizDTC)AuCl2] (3), [(TsPizDTC) AuCl2] (4), [(PizDTC)Au2Cl4] (5), [(MePizDTC)Au2Cl5] (6) and [(EtPizDTC)Au2Cl5] (7)) with cyclic amine-based dithiocarbamate have been synthesized, characterized and evaluated in vitro. The results indicate that these complexes exert selective cytotoxic effects against HL-60, BGC-823, Bel-7402 and KB cells lines. Complex 1 shows 11-, 5- and 1-folds higher cytotoxicity than cisplatin against KB, BGC-823 and Bel-7402 cell lines. Complex 2 exhibits higher cytotoxicity than cisplatin against BGC-823 and Bel-7402 cell lines. Complexes 3 and 4 display higher cytotoxicity than cisplatin against BGC-823 cell line. The nature of cyclic amine and the number of metal centers have important effects on cytotoxicity of these Au(III) complexes. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2013.02.010