acetic acid;1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine | 116993-63-6

• 英文名称: acetic acid;1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
• CAS: 116993-63-6
• 化学式: C12H20N6O2S
• 分子量: 312.39
• InChiKey: SLJQIKQUFMDEGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.69
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Combination of cimetidine and cysteine derivatives for treating cancer
  申请人：——

  公开号：US20030158118A1

  公开（公告）日：2003-08-21

  The present invention relates to new substances in the form of chemical complexes comprising cimetidine or a derivative thereof and a cysteine derivative and to compositions comprising said complexes or combination. The invention further relates to the therapeutic effect of such combinations in relation to treating cancer, cancer chemoprevention or the suppression of hypersensitivity and/or inflammatory reactions of a mammal.

  本发明涉及由西咪替丁或其衍生物和半胱氨酸衍生物组成的化学络合物形式的新物质，以及包含上述络合物或组合物的组合物。本发明进一步涉及此类复合物在治疗癌症、癌症化学预防或抑制哺乳动物超敏反应和/或炎症反应方面的治疗效果。
• Pharmaceutical formulations
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0257823B1

  公开（公告）日：1992-05-06
• US4996222A
  申请人：——

  公开号：US4996222A

  公开（公告）日：1991-02-26
• [EN] PHARMACEUTICAL FORMULATIONS
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：WO1988000825A1

  公开（公告）日：1988-02-11

  (EN) A stable pharmaceutical composition suitable for oral administration comprising a suspension of particulate cimetidine in an aqueous phase, and a suspending agent, wherein substantially all of the cimetidine present is of the polymorphic B form, and optionally any other pharmaceutical excipients.(FR) Une composition pharmaceutique stable à administration orale comprend une suspension de particules de cimétidine dans une phase aqueuse, un agent de suspension, la cimétidine présente dans la composition ayant exclusivement la forme B polymorphe, et facultativement d'autres excipients pharmaceutiques.
• [EN] COMBINATION OF CIMETIDINE AND CYSTEINE DERIVATIVES FOR TREATING CANCER<br/>[FR] COMBINAISON DE DERIVES DE CIMETIDINE ET DE CYSTEINE POUR TRAITER LE CANCER
  申请人：ASTION ONCOLOGY APS

  公开号：WO2003045359A2

  公开（公告）日：2003-06-05

  The present invention relates to new substances in the form of chemical complexes comprising cimetidine or a derivative thereof and a cysteine derivative and to compositions comprising said complexes or combination. The invention further relates to the therapeutic effect of such combinations in relation to treating cancer, cancer chemoprevention or the suppression of hypersensitivity and/or inflammatory reactions of a mammal.