| 1428427-92-2

• CAS: 1428427-92-2
• 化学式: C₁₂H₁₁ClN₂O₃Pt*H₂O
• 分子量: 479.779
• InChiKey: PNRPXQAVHVXUDK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  117.64
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-吡啶甲醇 、 potassium tetrachloroplatinate(II) 以 水 为溶剂， 反应 24.0h， 以55%的产率得到
  参考文献：
  名称：

  Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands

  摘要：

  Two new platinum(II) complexes, trans-[Pt(2-mpy)(2)]center dot 4H(2)O (1) and [PtCl(2-pyc)(2-hmpy)]center dot H2O (2), where 2-hmpy = 2-(hydroxymethyl)pyridine, 2-mpy = deprotonated 2-hmpy and 2-pyc = pyridine-2-carboxylate, have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray crystallography. The DNA binding affinities of these complexes for Fish Sperm DNA (FS-DNA) were investigated using fluorescence, viscosity, thermal denaturation and gel electrophoresis measurements. Fluorescence analysis indicates that complex 1 binds to DNA by a single intercalative mechanism, while complex 2 exhibits two types of interactions such as intercalation and covalent binding. Gel electrophoresis assay demonstrates ability of the complexes to cleavage the supercoiled 0311322 plasmid DNA. The in vitro cytotoxicities of both complexes were preliminarily evaluated and the cytotoxicity of complex 1 against the human lung cancer cells (H1299) is similar to oxaliplatin, but higher than transplatin and carboplatin. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.119