7-Chloro-N-(2-((ferrocenylmethyl)amino)ethyl)-4-(((2-((ferrocenylmethyl)amino)-ethyl))amino)quinolone-2-carboxamide | 1414872-52-8

• 英文名称: 7-Chloro-N-(2-((ferrocenylmethyl)amino)ethyl)-4-(((2-((ferrocenylmethyl)amino)-ethyl))amino)quinolone-2-carboxamide
• CAS: 1414872-52-8
• 化学式: C₃₆H₃₈ClFe₂N₅O
• 分子量: 703.878
• InChiKey: FJEBSGIAQNSJPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二茂铁甲醛 、 N-(2-Aminoethyl)-4-((2-aminoethyl)amino)-7-chloroquinoline-2-carboxamide 、 sodium tetrahydroborate 以 甲醇 为溶剂， 以23%的产率得到N-(2-Aminoethyl)-7-chloro-4-((2-((ferrocenylmethyl)amino)ethyl)amino)quinoline-2-carboxamide
  参考文献：
  名称：

  Synthesis and in vitro anticancer activity of ferrocenyl-aminoquinoline-carboxamide conjugates

  摘要：

  The syntheses and characterization of new multifunctional aminoquinoline-carboxamides and their ferrocene derivatives are reported, as well as their cytotoxicity against human colon adenocarcinoma (Caco-2, HTB-37), human breast carcinoma (HTB-129) and a normal cell line as a control (human normal breast epithelial cells MCF-10A, CRL-10317). All tested compounds showed higher activity against HTB-129 cells than against Caco-2 cells. The ferrocenyl-chloroquine amide conjugates displayed higher activity against both cancer cells than did their parent organic compounds. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.06.039