[Ph2Sn(ONHC(O)C6H4F-4)]2O | 830317-81-2

• 英文名称: [Ph2Sn(ONHC(O)C6H4F-4)]2O
• CAS: 830317-81-2
• 化学式: C₃₈H₃₀F₂N₂O₅Sn₂
• 分子量: 870.083
• InChiKey: SHXBPIRTIGZCAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  4-氟-N-羟基苯甲酰胺 、 二苯基氧化锡 以 甲醇 、 苯 为溶剂， 以65%的产率得到[Ph2Sn(ONHC(O)C6H4F-4)]2O
  参考文献：
  名称：

  Diorganotin(IV) derivatives of arylhydroxamic acids: synthesis, properties and antitumor activity

  摘要：

  Series of diorganotin(IV) complexes of 4-X-benzohydroxamic acid [X=NH2 (HL1), NO2 (HL2) or F (HL3)] formulated as [R2SnL2] and [R2Sn(L)](2)O (R=Me, Et, nBu or Ph) have been prepared and characterized by FT-IR, H-1,C-13 and Sn-119 NMR spectroscopies, elemental analyses, FAB(+)-MS and melting point determination. They are stable in air, soluble in alcohols and in hydroalcoholic solution and, in some cases, in water. Their in vitro antitumor activity against a series of human tumor cell lines was tested and, in a few of them, is identical to, or even higher than, that of cisplatin. For the mononuclear dialkyltin compounds, the activity generally increases with the length of the carbon chain of the alkyl ligand, being higher for the complexes with benzohydroxamato ligands bearing an electron-acceptor substituent (X=NO2 or F). No structure-activity relationship based on the Hammett's up constant, or related ones, has been recognized. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2004.08.025