| 612480-66-7

• CAS: 612480-66-7
• 化学式: C₉H₂₅Al₂NO
• 分子量: 217.267
• InChiKey: VNNCIZXVODQFBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  三甲基铝 、 聚甘氨酸 以 甲苯 为溶剂， 以15%的产率得到
  参考文献：
  名称：

  Structure and Reactivity of Organoaluminum Derivatives of Amino Acids

  摘要：

  The reaction of AlR3 with 1 molar equiv of anthranilic acid yields the dimeric carboxylates [R2Al(O2CC6H4-2-NH2)](2) [(R = Me (3a) or Et (3b)] in high yields. The addition of 2 molar equiv of AlR3 to anthranilic acid results in the formation of the tetranuclear complexes [R-2-Al](4)[mu-O2CC6H4-2-mu-NH](2) [(R = Me (4a) or Et (4b)], where both protic functionalities are involved in the alkane elimination. The addition of gamma-picoline to a solution of 4b in toluene results in a disruption of the tetranuclear cluster and affords Et2Al(eta-O2CC6H4-2-NH)AlEt2-(py-4-Me) (5). The reaction of 2 molar equiv of AlMe3 with glycine yields the alkylaluminum carboxylate Me2Al(O2CCH2NH2)AlMe3 (6), in which only the carboxylic group is deprotonated. When more equivalents of AlMe3 are employed, the alkylation of the carboxylate group of glycine occurs and the aluminum alkoxide Me2Al[OC(CH3)(2)CH2NH2]AlMe3 (7) was isolated as one of the products of the complex postreaction mixture. The resulting compounds have been characterized by NMR and IR spectroscopy, and the molecular structure of compounds 4b and 7 has been confirmed by X-ray crystallography. On the basis of the reported studies, the general pathway for an interaction of amino acids with aluminum alkyls is proposed and some new insight into the reaction mechanism of the carboxylate group alkylation is provided.

  DOI：

  10.1021/om030484i