| 1610785-54-0

• CAS: 1610785-54-0
• 化学式: C₃₃H₄₀Cl₂N₂O₄P₂Ru
• 分子量: 762.615
• InChiKey: WCCMXZZJWIPFNV-PMSDXGDUSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  8-氨基喹啉 、 RuCl2[(2S,2’S,3R,3’R)-MeO-bisdihydrobenzooxaphosphole](p-cymene) 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  胺可调谐的钌催化剂，用于酮的不对称还原

  摘要：

  AbstractA series of efficient ruthenium catalysts has been developed for the asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and selectivities. The new chiral bisdihydrobenzooxaphosphole (BIBOP)/diamine‐ruthenium complexes catalyzed the enantioselective hydrogenation of substrates such as aryl and heteroaryl cyclic and alkyl ketones with substrate/catalyst (S/C) ratios of up to 100,000. The opposite sense of enantioselectivity can be obtained by proper selection of a diamine with a given chirality of the phosphine. The usefulness of the new system has been demonstrated in the asymmetric hydrogenation of a complex synthetic intermediate towards cholesteryl ester transfer protein (CETP) inhibitors at S/C 20,000 on large‐scale operation.magnified image

  DOI：

  10.1002/adsc.201300727